Any feedback?
Literature summary for 1.1.1.205 extracted from
- Effect of mycophenolate acyl-glucuronide on human recombinant type 2 inosine monophosphate dehydrogenase (2009), Clin. Chem., 55, 986-993.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | at therapeutic concentrations in organ transplant patients, the effect of mycophenolic acid-acyl-glucuronide on IMPDHII activity is minimal compared to mycophenolic acid, and the quantification of mycophenolic acid metabolites for mycophenolate therapeutic drug monitoring and dose adjustment will be of no benefit | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | mycophenolic acid-phenyl-glucuronide has no effect | Homo sapiens | |
| Mycophenolic acid | uncompetitive inhibition | Homo sapiens |  |
| mycophenolic acid-acyl-glucuronide | uncompetitive inhibition, is a weaker inhibitor of IMPDH II than mycophenolic acid. When coincubated with mycophenolic acid, mycophenolic acid-acyl-glucuronide activity is negligible at pharmacological concentrations | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00157 | - |
NAD+ | - |
Homo sapiens | |
| 0.00455 | - |
inosine 5'-phosphate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| JURKAT cell | - |
Homo sapiens | - |
| lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IMPDH II | - |
Homo sapiens |
| type 2 inosine monophosphate dehydrogenase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000508 | - |
Mycophenolic acid | in the presence of NAD+ | Homo sapiens | |
| 0.0000577 | - |
Mycophenolic acid | in the presence of inosine 5'-phosphate | Homo sapiens | |
| 0.000382 | - |
mycophenolic acid-acyl-glucuronide | in the presence of NAD+ | Homo sapiens | |
| 0.000511 | - |
mycophenolic acid-acyl-glucuronide | in the presence of inosine 5'-phosphate | Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
