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Literature summary for 1.1.1.205 extracted from

  • Penuelas, S.; Noe, V.; Morales, R.; Ciudad, C.J.
    Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH (2005), Med. Sci. Monit., 11, BR6-BR12.
    View publication on PubMed

Application

Application Comment Organism
pharmacology the enzyme is a potential target as modulators in MTX chemotherapy of resistant cells, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of IMPDH2 in human erythroleukemia K562 cells, expression analysis, the enzyme expression affects the cytotoxicity of methotrexate, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzamide riboside
-
Homo sapiens
additional information inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate Homo sapiens
Mycophenolic acid
-
Homo sapiens
tiazofurin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme IMPDH2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
IMPDH2
-
Homo sapiens