Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme is a potential target as modulators in MTX chemotherapy of resistant cells, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression of IMPDH2 in human erythroleukemia K562 cells, expression analysis, the enzyme expression affects the cytotoxicity of methotrexate, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzamide riboside | - |
Homo sapiens | |
additional information | inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate | Homo sapiens | |
Mycophenolic acid | - |
Homo sapiens | |
tiazofurin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme IMPDH2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | inhibition of the enzyme in K562 cells sensitizes the before resistant cells to methotrexate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH2 | - |
Homo sapiens |