Literature summary for 1.1.1.205 extracted from

Chong, C.R.; Qian, D.Z.; Pan, F.; Wei, Y.; Pili, R.; Sullivan, D.J.; Liu, J.O.
Identification of type 1 inosine monophosphate dehydrogenase as an antiangiogenic drug target (2006), J. Med. Chem., 49, 2677-2680.

Search for more literature for 1.1.1.205

Application

Application	Comment	Organism
drug development	the IMPDH-1 is an antiangiogenic drug target	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of umbilical vein endothelial cell IMPDH-1 knockout lines	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Mycophenolic acid	IC50: 99.2 nM with umbilical vein endothelial cells, 128 nM with Jurkat cells, inhibits the enzyme in vivo and in vitro, mycophenolic acid inhibits tumor-associated angiogenesis and is used as clinical drug in immunosuppression	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	isozyme IMPDH-1 is essential for T lymphocyte development, enzyme inhibitor mycophenolic acid inhibits tumor-associated angiogenesis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B-lymphocyte	-	Homo sapiens	-
JURKAT cell	-	Homo sapiens	-
T-lymphocyte	-	Homo sapiens	-
umbilical vein endothelial cell	i.e. HUVEC	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	isozyme IMPDH-1 is essential for T lymphocyte development, enzyme inhibitor mycophenolic acid inhibits tumor-associated angiogenesis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
IMPDH-1	-	Homo sapiens
type 1 inosine monophosphate	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000992	-	IC50: 99.2 nM with umbilical vein endothelial cells, 128 nM with Jurkat cells, inhibits the enzyme in vivo and in vitro, mycophenolic acid inhibits tumor-associated angiogenesis and is used as clinical drug in immunosuppression	Homo sapiens	Mycophenolic acid
0.000128	-	IC50: 99.2 nM with umbilical vein endothelial cells, 128 nM with Jurkat cells, inhibits the enzyme in vivo and in vitro, mycophenolic acid inhibits tumor-associated angiogenesis and is used as clinical drug in immunosuppression	Homo sapiens	Mycophenolic acid

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Release 2023.1 (January 2023)