Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-cyanoindole-based inhibitors | synthesis and initial structureactivity relationships of 3-cyanoindole-based inhibitors with isozyme IMPDH II, IC50: 33-420 nM, comparison to other inhibitor structural classes, overview | Homo sapiens | |
BMS-337197 | isozyme IMPDH II IC50: 16 nM | Homo sapiens | |
Mycophenolic acid | isozyme IMPDH II IC50: 15 nM | Homo sapiens | |
VX-148 | isozyme IMPDH II IC50: 6 nM | Homo sapiens | |
VX-497 | isozyme IMPDH II IC50: 11 nM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | Homo sapiens | rate-limiting step of the de novo guanine nucleotide biosynthesis | xanthosine 5'-phosphate + NADH | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
IMPDH II | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphocyte | peripheral blood lymphocytes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH | - |
ir | |
inosine 5'-phosphate + NAD+ + H2O | rate-limiting step of the de novo guanine nucleotide biosynthesis | Homo sapiens | xanthosine 5'-phosphate + NADH | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Homo sapiens |
inosine monophosphate dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000006 | - |
isozyme IMPDH II IC50: 6 nM | Homo sapiens | VX-148 | |
0.000011 | - |
isozyme IMPDH II IC50: 11 nM | Homo sapiens | VX-497 | |
0.000015 | - |
isozyme IMPDH II IC50: 15 nM | Homo sapiens | Mycophenolic acid | |
0.000016 | - |
isozyme IMPDH II IC50: 16 nM | Homo sapiens | BMS-337197 | |
0.000033 | 0.00042 | synthesis and initial structureactivity relationships of 3-cyanoindole-based inhibitors with isozyme IMPDH II, IC50: 33-420 nM, comparison to other inhibitor structural classes, overview | Homo sapiens | 3-cyanoindole-based inhibitors |