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Literature summary for 1.1.1.205 extracted from

  • Heyde, E.; Nagabhushanam, A.; Vonarx, M.; Morrison, J.F.
    Studies on inosine monophosphate dehydrogenase. Steady state kinetics (1976), Biochim. Biophys. Acta, 429, 645-660.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
GMP competitive with respect to IMP, non competitive with respect to NAD+ and K+ Klebsiella aerogenes
Li+ competitive to K+ Klebsiella aerogenes
NADH poor inhibitor, product inhibition, non competitive Klebsiella aerogenes
nicotinic acid inhibitory analog of NAD+, non-competitive with respect to IMP and K+ Klebsiella aerogenes
xanthosine 5'-phosphate competitive with respect to IMP, non competitive with respect to NAD and K+ Klebsiella aerogenes

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
-
-

Reaction

Reaction Comment Organism Reaction ID
IMP + NAD+ + H2O = XMP + NADH + H+ IMP and K+ can bind randomly to the free enzyme, while NAD+ does not react unless K+ or both K+ and IMP are present on the enzyme Klebsiella aerogenes
IMP + NAD+ + H2O = XMP + NADH + H+ mechanism is partially random Klebsiella aerogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Klebsiella aerogenes xanthosine 5'-phosphate + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Klebsiella aerogenes

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Klebsiella aerogenes