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Literature summary for 1.1.1.201 extracted from
- Enzymatic routes for the synthesis of ursodeoxycholic acid (2014), J. Biotechnol., 191, 11-21.
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Clostridium sardiniense |
| synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Paeniclostridium sordellii |
| synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Fusarium equiseti |
| synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | [Clostridium] scindens |
| synthesis | the enzyme is useful in production of ursodeoxycholic acid, a secondary bile acid, which is used as a drug for the treatment of various liver diseases | Collinsella aerofaciens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Clostridium sardiniense |
| additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Paeniclostridium sordellii |
| additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Fusarium equiseti |
| additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | [Clostridium] scindens |
| additional information | development and evaluation of a selected multi-step reaction system for the synthesis of ursodeoxycholic acid, separation of each step by isolation of the intermediates using ultrafiltration membranes, overview | Collinsella aerofaciens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chenodeoxycholic acid + NADPH + H+ | Clostridium sardiniense | - |
ursodeoxycholic acid + NADP+ | - |
? |  |
| chenodeoxycholic acid + NADPH + H+ | Paeniclostridium sordellii | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | Fusarium equiseti | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | [Clostridium] scindens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | Collinsella aerofaciens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | Paeniclostridium sordellii | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | Fusarium equiseti | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | [Clostridium] scindens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | Collinsella aerofaciens | - |
ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | Clostridium sardiniense | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | ursodeoxycholic acid + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium sardiniense | - |
- |
- |
| Collinsella aerofaciens | - |
- |
- |
| Fusarium equiseti | - |
- |
- |
| Paeniclostridium sordellii | - |
- |
- |
| [Clostridium] scindens | - |
formerly Eubacterium sp. | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 350 | - |
pH and temperature not specified in the publication | Paeniclostridium sordellii |
| 350 | - |
pH and temperature not specified in the publication | [Clostridium] scindens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Clostridium sardiniense | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| 7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| 7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Fusarium equiseti | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| 7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
[Clostridium] scindens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| 7,12-dioxo-ursodeoxycholic acid + NADPH + H+ | - |
Collinsella aerofaciens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | - |
Clostridium sardiniense | ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | - |
Fusarium equiseti | ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | - |
[Clostridium] scindens | ursodeoxycholic acid + NADP+ | - |
? | |
| chenodeoxycholic acid + NADPH + H+ | - |
Collinsella aerofaciens | ursodeoxycholic acid + NADP+ | - |
? | |
| dehydrocholic acid + NADPH + H+ | - |
Clostridium sardiniense | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| dehydrocholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| dehydrocholic acid + NADPH + H+ | - |
Fusarium equiseti | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| dehydrocholic acid + NADPH + H+ | - |
[Clostridium] scindens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| dehydrocholic acid + NADPH + H+ | - |
Collinsella aerofaciens | 12-oxo-ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | - |
Clostridium sardiniense | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | - |
Paeniclostridium sordellii | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | - |
Fusarium equiseti | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | - |
[Clostridium] scindens | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | - |
Collinsella aerofaciens | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Clostridium sardiniense | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Paeniclostridium sordellii | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Fusarium equiseti | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | [Clostridium] scindens | ursodeoxycholic acid + NADP+ | - |
? | |
| lithocholic acid + NADPH + H+ | presence of both 7alpha-HSDH (EC 1.1.1.159) and 7beta-HSDH in one organism allows epimerization by a single bacterium | Collinsella aerofaciens | ursodeoxycholic acid + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 7beta-HSDH | - |
Clostridium sardiniense |
| 7beta-HSDH | - |
Paeniclostridium sordellii |
| 7beta-HSDH | - |
Fusarium equiseti |
| 7beta-HSDH | - |
[Clostridium] scindens |
| 7beta-HSDH | - |
Collinsella aerofaciens |
| 7beta-hydroxysteroid dehydrogenase | - |
Clostridium sardiniense |
| 7beta-hydroxysteroid dehydrogenase | - |
Paeniclostridium sordellii |
| 7beta-hydroxysteroid dehydrogenase | - |
Fusarium equiseti |
| 7beta-hydroxysteroid dehydrogenase | - |
[Clostridium] scindens |
| 7beta-hydroxysteroid dehydrogenase | - |
Collinsella aerofaciens |
| RUMGNA_02585 | - |
Fusarium equiseti |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | NADP+-dependent | Clostridium sardiniense | |
| NADP+ | NADP+-dependent | Paeniclostridium sordellii | |
| NADP+ | NADP+-dependent | Fusarium equiseti | |
| NADP+ | NADP+-dependent | [Clostridium] scindens | |
| NADP+ | NADP+-dependent | Collinsella aerofaciens | |
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