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Literature summary for 1.1.1.201 extracted from

  • Sutherland, J.D.; Williams, C.N.
    Bile acid induction of 7alpha- and 7beta-hydroxysteroid dehydrogenases in Clostridium limosum (1985), J. Lipid Res., 26, 344-350.
    View publication on PubMed
Search for more literature for 1.1.1.201

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
 3alpha,7beta-dihydroxy-5beta-cholanoic acid
-
 Hathewaya limosa
0.076
-
 3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid
-
 Hathewaya limosa
0.14
-
 NADP+
-
 Hathewaya limosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+ Hathewaya limosa ursocholic acid 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
-
 ?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ Hathewaya limosa ursodeoxycholic acid 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
 ?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ Hathewaya limosa active on both free and conjugated bile salts 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
 ?

Organism

Organism UniProt Comment Textmining
Hathewaya limosa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture bile salt induction of enzymes synthesis Hathewaya limosa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3alpha,7beta,12alpha-trihydroxy-5beta-cholanoic acid + NADP+ ursocholic acid Hathewaya limosa 3alpha,12alpha-dihydroxy-7-keto-5beta-cholanoic acid + NADPH
-
 ?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ ursodeoxycholic acid Hathewaya limosa 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
 ?
3alpha,7beta-dihydroxy-5beta-cholanoic acid + NADP+ active on both free and conjugated bile salts Hathewaya limosa 3alpha-hydroxy-7-oxo-5beta-cholanoic acid + NADPH
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.8 10.5
-
 Hathewaya limosa

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Hathewaya limosa