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Literature summary for 1.1.1.2 extracted from
- Characterization of aldose reductase and aldehyde reductase from rat testis (1989), Biochim. Biophys. Acta, 996, 30-36.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alconil | - |
Rattus norvegicus |  |
| E79175 | - |
Rattus norvegicus | |
| epalrestat | - |
Rattus norvegicus | |
| NaCl | - |
Rattus norvegicus | |
| NH4Cl | - |
Rattus norvegicus | |
| sorbinil | - |
Rattus norvegicus | |
| Statil | - |
Rattus norvegicus | |
| Tolrestat | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
NADPH | - |
Rattus norvegicus | |
| 6.42 | - |
D-glucuronate | - |
Rattus norvegicus | |
| 8.35 | - |
DL-glyceraldehyde | - |
Rattus norvegicus | |
| 2080 | - |
D-xylose | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 41000 | - |
SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Rattus norvegicus | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Rattus norvegicus | - |
glycerol + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 6.84 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
| D-xylose + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
| glycerol + NADP+ | - |
Rattus norvegicus | DL-glyceraldehyde + NADPH + H+ | - |
? | |
| L-glyceraldehyde + NADPH | - |
Rattus norvegicus | glycerol + NADP+ | - |
r | |
| additional information | enzyme is virtually inactive for aldo-sugars | Rattus norvegicus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | aldehyde reductase II utilizes only NADPH as cofactor | Rattus norvegicus | |
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