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Literature summary for 1.1.1.2 extracted from
- Purification and properties of an NADPH-linked aldehyde reductase from rat kidney (1983), Biochim. Biophys. Acta, 748, 444-452.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alrestatin | - |
Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.004 | - |
n-octadecanal | - |
Rattus norvegicus | |
| 0.008 | - |
n-hexadecanal | - |
Rattus norvegicus | |
| 0.014 | - |
n-tetradecanal | - |
Rattus norvegicus | |
| 0.019 | - |
n-dodecanal | enzyme from brain | Rattus norvegicus | |
| 0.02 | - |
n-dodecanal | enzyme from liver and kidney | Rattus norvegicus | |
| 0.07 | - |
n-decanal | - |
Rattus norvegicus | |
| 0.2 | - |
p-nitrobenzaldehyde | enzyme from kidney, brain or liver | Rattus norvegicus | |
| 0.77 | - |
n-octanal | - |
Rattus norvegicus | |
| 1.2 | - |
4-Pyridinecarboxaldehyde | enzyme from kidney, brain or liver | Rattus norvegicus | |
| 3.3 | - |
propionaldehyde | - |
Rattus norvegicus | |
| 3.8 | - |
acetaldehyde | - |
Rattus norvegicus | |
| 24 | - |
ethyl acetoacetate | enzyme from brain or liver | Rattus norvegicus | |
| 25 | - |
ethyl acetoacetate | enzyme from kidney | Rattus norvegicus | |
| 42 | - |
D-glucuronate | enzyme from brain | Rattus norvegicus | |
| 43 | - |
D-glucuronate | enzyme from kidney, or liver | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Bos taurus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
- |
Bos taurus |
| 32000 | - |
gel filtration | Rattus norvegicus |
| 37000 | - |
1 * 37000, SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethylacetoacetate + NADPH | Rattus norvegicus | - |
ethyl L-(+)-3-hydroxybutyrate + NADP+ | - |
? | |
| succinic semialdehyde + NADPH + H+ | Rattus norvegicus | - |
4-hydroxybutyrate + NADP+ | - |
? | |
| succinic semialdehyde + NADPH + H+ | Bos taurus | - |
4-hydroxybutyrate + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
bovine | - |
| Cavia porcellus | - |
guinea pig | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| heart | - |
Cavia porcellus | - |
| heart | - |
Rattus norvegicus | - |
| heart | muscle | Bos taurus | - |
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Bos taurus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 5.9 | - |
liver enzyme | Rattus norvegicus |
| 6 | - |
brain enzyme | Rattus norvegicus |
| 11.02 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-pyridinecarboxaldehyde + NADPH | - |
Rattus norvegicus | 4-pyridinemethanol + NADP+ | - |
r | |
| acetaldehyde + NADPH + H+ | - |
Rattus norvegicus | ethanol + NADP+ | - |
? | |
| daunorubicin + NADPH | - |
Rattus norvegicus | ? + NADP+ | - |
? | |
| ethylacetoacetate + NADPH | - |
Rattus norvegicus | ethyl L-(+)-3-hydroxybutyrate + NADP+ | - |
? | |
| n-decanal + NADPH + H+ | - |
Rattus norvegicus | n-decanol + NADP+ | - |
r | |
| n-dodecanal + NADPH + H+ | - |
Rattus norvegicus | n-dodecanol + NADP+ | - |
r | |
| n-hexadecanal + NADPH + H+ | - |
Rattus norvegicus | n-hexadecanol + NADP+ | - |
r | |
| n-octadecanal + NADPH + H+ | - |
Rattus norvegicus | n-octadecanol + NADP+ | - |
r | |
| n-octanal + NADPH + H+ | - |
Rattus norvegicus | n-octanol + NADP+ | - |
r | |
| n-tetradecanal + NADPH + H+ | - |
Rattus norvegicus | n-tetradecanol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Rattus norvegicus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Bos taurus | p-nitrobenzylalcohol + NADP+ | - |
r | |
| propionaldehyde + NADPH | - |
Rattus norvegicus | propanol + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Rattus norvegicus | 4-hydroxybutyrate + NADP+ | - |
? | |
| succinic semialdehyde + NADPH + H+ | - |
Rattus norvegicus | 4-hydroxybutyrate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | - |
Bos taurus | 4-hydroxybutyrate + NADP+ | - |
? | |
| succinic semialdehyde + NADPH + H+ | - |
Bos taurus | 4-hydroxybutyrate + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Bos taurus |
| monomer | 1 * 37000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
for reduction of p-pyridinecarboxaldehyde | Rattus norvegicus |
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Release 2023.1 (January 2023)
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