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Literature summary for 1.1.1.197 extracted from

  • Fujimori, K.; Okada, T.; Urade, Y.
    Expression of NADP(+)-Dependent 15-Hydroxyprostaglandin Dehydrogenase mRNA in Monkey Ocular Tissues and Characterization of Its Recombinant Enzyme (2002), J. Biochem., 131, 383-389.
    View publication on PubMed
Search for more literature for 1.1.1.197

Cloned(Commentary)

Cloned (Comment) Organism
-
 Macaca fascicularis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30500
-
 x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE Macaca fascicularis
31000
-
 x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE Macaca fascicularis

Organism

Organism UniProt Comment Textmining
Macaca fascicularis Q8MI29
-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye epithelial cells of cornea Macaca fascicularis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0012
-
 substrate latanoprost, pH 7.0, 25°C Macaca fascicularis
0.0022
-
 substrate acid form of latanoprost, pH 7.0, 25°C Macaca fascicularis
0.0061
-
 substrate prostaglandin F2alpha, cosubstrate NAD+, pH 7.0, 25°C Macaca fascicularis
0.0098
-
 substrate prostaglandin E2, cosubstrate NADP+, pH 7.0, 25°C Macaca fascicularis
0.0243
-
 substrate prostaglandin F2alpha, cosubstrate NADP+, pH 7.0, 25°C Macaca fascicularis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acid form of latanoprost + NADP+
-
 Macaca fascicularis ? + NADPH
-
 ?
latanoprost + NADP+
-
 Macaca fascicularis ? + NADPH
-
 ?
prostaglandin E2 + NADPH + H+
-
 Macaca fascicularis prostaglandin F2alpha + NADP+
-
 ?
prostaglandin F2alpha + NADP+
-
 Macaca fascicularis prostaglandin E1 + NADPH
-
 ?

Subunits

Subunits Comment Organism
? x * 30500, deduced from gene sequence, x * 31000, SDS-PAGE Macaca fascicularis

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Macaca fascicularis