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Literature summary for 1.1.1.19 extracted from
- Vitamin C. Biosynthesis, recycling and degradation in mammals (2007), FEBS J., 274, 1-22.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sorbinil | - |
Homo sapiens |  |
| sorbinil | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.33 | - |
D-glucuronate | - |
Homo sapiens | |
| 0.69 | - |
D-glucuronolactone | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
| endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Rattus norvegicus | a step in ascorbic acid biosynthesis, overview | L-gulonate + NADP+ | - |
r | |
| D-glucuronolactone + NADPH | Homo sapiens | - |
L-gulonolactone + NADP+ | - |
r | |
| D-glucuronolactone + NADPH | Rattus norvegicus | - |
L-gulonolactone + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | a step in ascorbic acid biosynthesis, overview | Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
| D-glucuronolactone + NADPH | - |
Homo sapiens | L-gulonolactone + NADP+ | - |
r | |
| D-glucuronolactone + NADPH | - |
Rattus norvegicus | L-gulonolactone + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Homo sapiens |
| monomer | - |
Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AKR1A1 | - |
Homo sapiens |
| AKR1A1 | - |
Rattus norvegicus |
| aldehyde reductase | - |
Homo sapiens |
| aldehyde reductase | - |
Rattus norvegicus |
| More | the enzyme belongs to the aldo-keto reductase superfamily | Homo sapiens |
| More | the enzyme belongs to the aldo-keto reductase superfamily | Rattus norvegicus |
| TPN l-hexonate dehydrogenase | - |
Homo sapiens |
| TPN l-hexonate dehydrogenase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | dependent on | Homo sapiens | |
| NADP+ | dependent on | Rattus norvegicus | |
| NADPH | dependent on | Homo sapiens | |
| NADPH | dependent on | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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