Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.189 extracted from

  • Schlegel, W.; Kruger, S.; Korte, K.
    Purification of prostaglandin E2-9-oxoreductase from human decidua vera (1984), FEBS Lett., 171, 141-144.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Ca2+ equimolar to substrate, 15% activation Homo sapiens
Oxytocin equimolar to substrate, 19% activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
17beta-estradiol equimolar to substrate inhibits 49% of enzyme activity Homo sapiens
aspirin equimolar to substrate inhibits 65% of enzyme activity Homo sapiens
cortisol equimolar to substrate inhibits 55% of enzyme activity Homo sapiens
indomethacin equimolar to substrate inhibits 81% of enzyme activity Homo sapiens
lonazolac equimolar to substrate inhibits 78% of enzyme activity Homo sapiens
progesterone equimolar to substrate inhibits 69% of enzyme activity Homo sapiens
vitamin D3 equimolar to substrate inhibits 38% of enzyme activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
NADPH
-
Homo sapiens
0.08
-
prostaglandin E2
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ Homo sapiens might be an important factor in the cascade of events leading to uterine contractions and parturition (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
decidua parietalis
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00038
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
r
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ might be an important factor in the cascade of events leading to uterine contractions and parturition Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
forward reaction Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens