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Literature summary for 1.1.1.188 extracted from

  • Diaz-Viraque, F.; Chiribao, M.L.; Trochine, A.; Gonzalez-Herrera, F.; Castillo, C.; Liempi, A.; Kemmerling, U.; Maya, J.D.; Robello, C.
    Old yellow enzyme from Trypanosoma cruzi exhibits in vivo prostaglandin F2alpha synthase activity and has a key role in parasite infection and drug susceptibility (2018), Front. Immunol., 9, 456 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine mice infected with PGFS overexpressing parasites show an early parasitemia peak and higher heart muscle parasitic load Trypanosoma cruzi

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Trypanosoma cruzi 5829
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi V5BT91
-
-
Trypanosoma cruzi Dm28c V5BT91
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Trypanosoma cruzi
-
epimastigote
-
 Trypanosoma cruzi
-

Synonyms

Synonyms Comment Organism
TCDM_00059
-
 Trypanosoma cruzi

General Information

General Information Comment Organism
physiological function PGFS overexpressing parasites are less able to complete the infective cycle in cell culture infections and increase cardiac tissue parasitic load in infected mice. Parasites overexpressing the enzyme increase PGF2alpha synthesis from arachidonic acid and display increased susceptibility to benznidazole and nifurtimox but increased resistance to hydrogen peroxide Trypanosoma cruzi