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Literature summary for 1.1.1.188 extracted from

  • Siemieniuch, M.J.; Jursza, E.; Kowalewski, M.P.; Majewska, M.; Skarzynski, D.J.
    Prostaglandin endoperoxide synthase 2 (PTGS2) and prostaglandins F2alpha and E2 synthases (PGFS and PGES) expression and prostaglandin F2alpha and E2 secretion following oestrogen and/or progesterone stimulation of the feline endometrium (2013), Reprod. Domest. Anim., 48, 72-78.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene PGFS, DNA and amino acid sequence determination and analysis Felis catus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostaglandin H2 + NADP+ Felis catus
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prostaglandin F2alpha + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Felis catus E2IGW3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
uterine endometrium at oestrus and mid and late phases of pseudopregnancy Felis catus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin H2 + NADP+
-
Felis catus prostaglandin F2alpha + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
9,11-endoperoxidase reductase
-
Felis catus
PGF2alpha synthase
-
Felis catus
PGFS
-
Felis catus
prostaglandin F2alpha synthase
-
Felis catus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Felis catus

Expression

Organism Comment Expression
Felis catus treatment with estradiol and/or progesterone affects neither PGF2alpha secretion nor enzyme PGFS expression at any phase after 12 h of culture, while related enzymes PG-endoperoxide synthase (PTGS2) and PGE2 synthase (PGES) are both upregulated by estradiol and progesterone during pseudopregnancy additional information
Felis catus expression is significantly up-regulated by oestradiol plus progesterone at oestrus and the mid phase of pseudopregnancy and is also up-regulated by a single treatment with progesterone at late pseudopregnancy. Simultaneous incubation with oestradiol and progesterone up-regulates prostaglandin-endoperoxide synthase PTGS2 gene expression at oestrus and mid-luteal phase. Treatment with oestradiol and /or progesterone affects neither prostaglandin F2alpha secretion nor prostaglandin F2alpha synthase expression at any phase after 12 h of culture up

General Information

General Information Comment Organism
metabolism the prostaglandin H2 (PGH2) is the common precursor of prostaglandin F2alpha (PGF2alphha) and prostaglandin E2 (PGE2). PGH2 is converted into one of the active prostaglandins by a specific terminal synthase, such as PGE2 synthase (PGES), which is responsible for PGE2 production or 9,11-endoperoxidase reductase, which has PGF2alpha synthase (PGFS) activity Felis catus