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Literature summary for 1.1.1.184 extracted from

  • Rotondo, R.; Moschini, R.; Renzone, G.; Tuccinardi, T.; Balestri, F.; Cappiello, M.; Scaloni, A.; Mura, U.; Del-Corso, A.
    Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation (2016), Free Radic. Biol. Med., 99, 323-332.
    View publication on PubMed
Search for more literature for 1.1.1.184

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0045
-
 NADPH pH 8.4, 25°C Homo sapiens
0.0065
-
 3-glutathionyl-nonanal pH 8.4, 25°C Homo sapiens
0.0207
-
 3-glutathionyl-propanal pH 8.4, 25°C Homo sapiens
0.0238
-
 3-glutathionyl-hexanal pH 8.4, 25°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P16152
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-glutathionyl-4-hydroxynonanal + NADP+
-
 Homo sapiens 3-glutathionyl nonanoic-delta-lactone + NADPH + H+ oxidation of the hemiacetal form of 3-glutathionyl-4-hydroxynonanal, generating the 3-glutathionyl nonanoic-delta-lactone ?
3-glutathionyl-4-hydroxynonanal + NADPH + H+
-
 Homo sapiens 3-glutathionyl-1,4-dihydroxynonane + NADP+
-
 ?
3-glutathionyl-hexanal + NADPH + H+
-
 Homo sapiens 3-glutathionyl-hexan-1-ol + NADP+
-
 ?
3-glutathionyl-nonanal + NADPH + H+
-
 Homo sapiens 3-glutathionyl-nonan-1-ol + NADP+
-
 ?
3-glutathionyl-propanal + NADPH + H+
-
 Homo sapiens 3-glutathionyl-propan-1-ol + NADP+
-
 ?
additional information the presence of the glutathionyl moiety in the substrates appears as a necessary requirement for the susceptibility by hCBR1. The corresponding alkanals and alkenals, and the cysteinyl and gamma-glutamyl-cysteinylalkanals adducts are either ineffective or very poorly active as CBR1 substrates Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
hCBR1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
23.8
-
 NADPH pH 8.4, 25°C Homo sapiens
30.5
-
 3-glutathionyl-hexanal pH 8.4, 25°C Homo sapiens
30.8
-
 3-glutathionyl-nonanal pH 8.4, 25°C Homo sapiens
190.8
-
 3-glutathionyl-propanal pH 8.4, 25°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
885
-
 3-glutathionyl-propanal pH 8.4, 25°C Homo sapiens
1281
-
 3-glutathionyl-hexanal pH 8.4, 25°C Homo sapiens
4615
-
 3-glutathionyl-nonanal pH 8.4, 25°C Homo sapiens
5185
-
 NADPH pH 8.4, 25°C Homo sapiens