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Literature summary for 1.1.1.184 extracted from

  • Endo, S.; Matsunaga, T.; Nagano, M.; Abe, H.; Ishikura, S.; Imamura, Y.; Hara, A.
    Characterization of an oligomeric carbonyl reductase of dog liver: its identity with peroxisomal tetrameric carbonyl reductase (2007), Biol. Pharm. Bull., 30, 1787-1791.
    View publication on PubMed
Search for more literature for 1.1.1.184

Cloned(Commentary)

Cloned (Comment) Organism
-
 Canis lupus familiaris

Inhibitors

Inhibitors Comment Organism Structure
5beta-cholanoic acid
-
 Canis lupus familiaris
bromosulfophthalein
-
 Canis lupus familiaris
Dehydrolithocholic acid
-
 Canis lupus familiaris
Flufenamic acid
-
 Canis lupus familiaris
genistein
-
 Canis lupus familiaris
kaempferol
-
 Canis lupus familiaris
lithocholic acid
-
 Canis lupus familiaris
myristic acid
-
 Canis lupus familiaris
quercetin
-
 Canis lupus familiaris
Valproic acid
-
 Canis lupus familiaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 9,10-phenanthrenequinone pH 6.0 Canis lupus familiaris
0.008
-
 benzoylformic acid ethyl ester pH 6.0 Canis lupus familiaris
0.009
-
 all-trans-retinal pH 7.4 Canis lupus familiaris
0.009
-
 1-phenylisatin pH 6.0 Canis lupus familiaris
0.01
-
 valerophenone pH 6.0 Canis lupus familiaris
0.011
-
 hexanophenone pH 6.0 Canis lupus familiaris
0.018
-
 heptanophenone pH 6.0 Canis lupus familiaris
0.02
-
 acenaphthenequinone pH 6.0 Canis lupus familiaris
0.028
-
 S-1-phenyl-1-butanol pH 7.4 Canis lupus familiaris
0.029
-
 n-butyrophenone pH 6.0 Canis lupus familiaris
0.036
-
 16-ketoestrone pH 7.4 Canis lupus familiaris
0.044
-
 4-hexanoylpyridine pH 6.0 Canis lupus familiaris
0.047
-
 isatin pH 7.4 Canis lupus familiaris
0.061
-
 menadione pH 6.0 Canis lupus familiaris
0.064
-
 isatin pH 6.0 Canis lupus familiaris
0.086
-
 all-trans-retinol pH 7.4 Canis lupus familiaris
0.087
-
 9-cis-retinal pH 7.4 Canis lupus familiaris
0.099
-
 16-ketoestrone pH 6.0 Canis lupus familiaris
0.22
-
 2,3-heptanedione pH 6.0 Canis lupus familiaris
0.4
-
 4-benzoylpyridine pH 6.0 Canis lupus familiaris
0.62
-
 2,3-Hexanedione pH 6.0 Canis lupus familiaris
3.9
-
 2,3-Pentanedione pH 6.0 Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome sequence contains peroxisomal targeting signal Ser-His-Leu Canis lupus familiaris 5777
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 4 * 27000, SDS-PAGE Canis lupus familiaris
100000
-
 gel filtration Canis lupus familiaris

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver major form of soluble NADPH-dependent all-trans-retinal dehydrogenase in liver Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phenylisatin + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
16-ketoestrone + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
2,3-heptanedione + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
2,3-hexanedione + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
2,3-pentanedione + NADPH + H+
-
 Canis lupus familiaris ? + NADP+
-
 r
4-benzoylpyridine + NADPH + H+
-
 Canis lupus familiaris (S)-alpha-phenyl-4-pyridylmethanol + NADP+
-
 ?
4-hexanoylpyridine + NADPH
-
 Canis lupus familiaris 1-(pyridin-4-yloxy)hexan-1-ol + NADP+
-
 ?
9,10-phenanthrenequinone + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
9-cis-retinal + NADPH + H+
-
 Canis lupus familiaris 9-cis-retinol + NADP+
-
 ?
acenaphthenequinone + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
all-trans-retinal + NADPH + H+
-
 Canis lupus familiaris all-trans-retinol + NADP+
-
 r
all-trans-retinol + NADP+
-
 Canis lupus familiaris all-trans-retinal + NADPH
-
 r
benzoylformic acid ethyl ester + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
heptanophenone + NADPH
-
 Canis lupus familiaris 1-phenylheptan-1-ol + NADP+
-
 ?
hexanophenone + NADPH
-
 Canis lupus familiaris 1-phenylhexan-1-ol + NADP+
-
 ?
isatin + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 r
menadione + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 ?
n-butyrophenone + NADPH
-
 Canis lupus familiaris 1-phenylbutan-1-ol + NADP+
-
 ?
S-1-phenyl-1-butanol + NADPH
-
 Canis lupus familiaris ? + NADP+
-
 ?
valerophenone + NADPH
-
 Canis lupus familiaris 1-phenylpentan-1-ol + NADP+
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 27000, SDS-PAGE Canis lupus familiaris

Synonyms

Synonyms Comment Organism
peroxisomal-type carbonyl reductase
-
 Canis lupus familiaris
PTCR
-
 Canis lupus familiaris

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.01
-
 all-trans-retinol pH 7.4 Canis lupus familiaris
0.07
-
 9-cis-retinal pH 7.4 Canis lupus familiaris
0.08
-
 all-trans-retinal pH 7.4 Canis lupus familiaris
0.51
-
 menadione pH 6.0 Canis lupus familiaris
3.5
-
 S-1-phenyl-1-butanol pH 7.4 Canis lupus familiaris
6.3
-
 isatin pH 7.4 Canis lupus familiaris
6.8
-
 16-ketoestrone pH 7.4 Canis lupus familiaris
10
-
 heptanophenone pH 6.0 Canis lupus familiaris
11
-
 valerophenone pH 6.0 Canis lupus familiaris
13
-
 acenaphthenequinone pH 6.0 Canis lupus familiaris
14
-
 isatin pH 6.0 Canis lupus familiaris
15
-
 n-butyrophenone pH 6.0 Canis lupus familiaris
17
-
 4-benzoylpyridine pH 6.0 Canis lupus familiaris
17
-
 4-hexanoylpyridine pH 6.0 Canis lupus familiaris
17
-
 1-phenylisatin pH 6.0 Canis lupus familiaris
20
-
 9,10-phenanthrenequinone pH 6.0 Canis lupus familiaris
20
-
 16-ketoestrone pH 6.0 Canis lupus familiaris
23
-
 2,3-Pentanedione pH 6.0 Canis lupus familiaris
23
-
 2,3-heptanedione pH 6.0 Canis lupus familiaris
24
-
 2,3-Hexanedione pH 6.0 Canis lupus familiaris
25
-
 hexanophenone pH 6.0 Canis lupus familiaris
32
-
 benzoylformic acid ethyl ester pH 6.0 Canis lupus familiaris

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0021
-
 pH 6.0 Canis lupus familiaris 5beta-cholanoic acid
0.0033
-
 pH 6.0 Canis lupus familiaris lithocholic acid
0.0061
-
 pH 6.0 Canis lupus familiaris genistein
0.011
-
 pH 6.0 Canis lupus familiaris myristic acid
0.015
-
 pH 6.0 Canis lupus familiaris Dehydrolithocholic acid
0.017
-
 pH 6.0 Canis lupus familiaris kaempferol
0.022
-
 pH 6.0 Canis lupus familiaris quercetin
0.023
-
 pH 6.0 Canis lupus familiaris bromosulfophthalein
0.035
-
 pH 6.0 Canis lupus familiaris Valproic acid
0.055
-
 pH 6.0 Canis lupus familiaris Flufenamic acid