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Literature summary for 1.1.1.176 extracted from
- Deoxycholic acid transformations catalyzed by selected filamentous fungi (2016), Steroids, 107, 20-29.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Curvularia lunata | - |
- |
- |
| Curvularia lunata VKM F-644 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxycholate + NADP+ | 3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid | Curvularia lunata | 12-oxo-lithocholic acid + NADPH + H+ | i.e. 3alpha-hydroxy-12-oxo-5beta-cholan-24-oic acid | ? |  |
| deoxycholate + NADP+ | 3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid | Curvularia lunata VKM F-644 | 12-oxo-lithocholic acid + NADPH + H+ | i.e. 3alpha-hydroxy-12-oxo-5beta-cholan-24-oic acid | ? | |
| additional information | reaction product analysis confirmed by MS and NMR analyses | Curvularia lunata | ? | - |
? | |
| additional information | reaction product analysis confirmed by MS and NMR analyses | Curvularia lunata VKM F-644 | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Curvularia lunata | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | deoxycholic acid transformation by fungal strains, detailed overview. Identification of several strains capable of producing cholic acid, ursocholic acid, 12-oxo-lithocholic acid, and 3-oxo-deoxycholic acid as major products from deoxycholic acid | Curvularia lunata |
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Release 2023.1 (January 2023)
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