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Literature summary for 1.1.1.17 extracted from
- Zn2+-induced cooperativity of mannitol-1-phosphate dehydrogenase from Aspergillus parasiticus (1985), J. Biol. Chem., 260, 10019-10022.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | competitive inhibition | Aspergillus niger |  |
| Cd2+ | cooperative binding | Aspergillus parasiticus | |
| Co2+ | competitive inhibition | Aspergillus niger | |
| Co2+ | cooperative binding | Aspergillus parasiticus | |
| Cu2+ | irreversible inactivation | Aspergillus niger | |
| Cu2+ | irreversible inactivation | Aspergillus parasiticus | |
| Hg2+ | irreversible inactivation | Aspergillus niger | |
| Hg2+ | irreversible inactivation | Aspergillus parasiticus | |
| Ni2+ | competitive inhibition | Aspergillus niger | |
| Ni2+ | cooperative binding | Aspergillus parasiticus | |
| Zn2+ | competitive with respect to D-fructose 6-phosphate, noncompetitive inhibition with respect to NADH | Aspergillus niger | |
| Zn2+ | cooperative binding of Zn2+, competitive type if KCl concentration is greater 100 mM, sigmoidal type at lower salt concentrations | Aspergillus parasiticus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| intracellular | - |
Aspergillus niger | 5622 | - |
| intracellular | - |
Aspergillus parasiticus | 5622 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
gel filtration | Aspergillus niger |
| 40000 | - |
gel filtration | Aspergillus parasiticus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-mannitol 1-phosphate + NAD+ | Aspergillus niger | - |
D-fructose 6-phosphate + NADH + H+ | - |
r | |
| D-mannitol 1-phosphate + NAD+ | Aspergillus parasiticus | - |
D-fructose 6-phosphate + NADH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus niger | - |
- |
- |
| Aspergillus parasiticus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, chromatography techniques | Aspergillus niger |
| to homogeneity, chromatography techniques | Aspergillus parasiticus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Aspergillus niger | - |
| cell culture | - |
Aspergillus parasiticus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 150 | - |
- |
Aspergillus niger |
| 190 | - |
- |
Aspergillus parasiticus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-mannitol 1-phosphate + NAD+ | - |
Aspergillus niger | D-fructose 6-phosphate + NADH + H+ | - |
r | |
| D-mannitol 1-phosphate + NAD+ | - |
Aspergillus parasiticus | D-fructose 6-phosphate + NADH + H+ | - |
r | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
half-life: 2 h, decreasing stability in the presence of zinc ions | Aspergillus parasiticus |
| 30 | - |
half-life: above 280 min | Aspergillus niger |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Aspergillus niger | |
| NAD+ | - |
Aspergillus parasiticus | |
| NADH | - |
Aspergillus niger | |
| NADH | - |
Aspergillus parasiticus | |
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