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Literature summary for 1.1.1.169 extracted from
- Ketopantoate reductase activity is only encoded by ilvC in Corynebacterium glutamicum (2003), J. Biotechnol., 104, 253-260.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ilvC, complementation of an enzyme-deficient Escherichia coli mutant strain | Corynebacterium glutamicum |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.4 | - |
2-oxopantoate | 30°C, pH 7.5 | Corynebacterium glutamicum |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxopantoate + NADPH | Corynebacterium glutamicum | reaction is part of the D-pantothenate biosynthesis | (R)-pantoate + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Corynebacterium glutamicum | - |
gene ilvC, the enzyme activity in the organism is only encoded by ilvC, a bifunctional enzyme showing acetohydroxyacid isomeroreductase and 2-hydropantoate 2-reductase activity | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0126 | - |
wild-type strain | Corynebacterium glutamicum |
| 0.0246 | - |
recombinant Escherichia coli mutant strain expresing the enzyme | Corynebacterium glutamicum |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxopantoate + NADPH | - |
Corynebacterium glutamicum | (R)-pantoate + NADP+ | - |
? | |
| 2-oxopantoate + NADPH | reaction is part of the D-pantothenate biosynthesis | Corynebacterium glutamicum | (R)-pantoate + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ilvC | - |
Corynebacterium glutamicum |
| ketopantoate reductase | - |
Corynebacterium glutamicum |
| KPR | - |
Corynebacterium glutamicum |
| More | gene ilvC encodes a acetohydroxyacid isomeroreductase which also shows 2-hydropantoate 2-reductase activity | Corynebacterium glutamicum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Corynebacterium glutamicum | |
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Release 2023.1 (January 2023)
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