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Literature summary for 1.1.1.153 extracted from
- Localization of sepiapterin reductase in the human brain (2002), Brain Res., 954, 237-246.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3, pLysS) | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
SDS-PAGE | Mus musculus |
| 30000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | final step in the synthesis of tetrahydrobiopterin | ? | - |
? |  |
| additional information | Homo sapiens | final step in the synthesis of tetrahydrobiopterin | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant protein using His-tag | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain stem | monoaminergic field, neurons | Homo sapiens | - |
| caudate nucleus | - |
Homo sapiens | - |
| cerebral cortex | pyramidal neurons | Homo sapiens | - |
| cerebral gray matter | - |
Homo sapiens | - |
| cerebral white matter | - |
Homo sapiens | - |
| hypothalamus | neurons | Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| medulla oblongata | dorsal and ventral parts | Homo sapiens | - |
| oliva | neurons | Homo sapiens | - |
| substantia nigra | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | final step in the synthesis of tetrahydrobiopterin | Mus musculus | ? | - |
? | |
| additional information | final step in the synthesis of tetrahydrobiopterin | Homo sapiens | ? | - |
? | |
| sepiapterin + NADPH + H+ | - |
Mus musculus | 7,8-dihydrobiopterin + NADP+ | - |
? | |
| sepiapterin + NADPH + H+ | - |
Homo sapiens | 7,8-dihydrobiopterin + NADP+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
| NADPH | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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