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Literature summary for 1.1.1.153 extracted from

  • Sueoka, T.; Katoh, S.
    Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes (1985), Biochim. Biophys. Acta, 843, 193-198.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-Carboxypterin IC50 0.03 mM Rattus norvegicus
alpha-ketoglutarate slight, IC50 5 mM Rattus norvegicus
Cd2+ IC50 0.1 mM Rattus norvegicus
dicoumarol IC50 0.0006 mM Rattus norvegicus
Ethacrynic acid IC50 0.03 mM Rattus norvegicus
Hg2+ IC50 0.00009 mM Rattus norvegicus
indomethacin IC50 0.06 mM Rattus norvegicus
N-acetylserotonin IC50 0.0006 mM Rattus norvegicus
Phenobarbital slight, IC50 0.6 mM Rattus norvegicus
propionic acid IC50 0.3 mM, pH 6.4 Rattus norvegicus
pyrazole slight, IC50 1 mM Rattus norvegicus
rutin IC50 0.06 mM Rattus norvegicus
Zn2+ IC50 0.4 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00082
-
9,10-phenanthrene quinone
-
Rattus norvegicus
0.0183
-
benzil
-
Rattus norvegicus
0.043
-
benzylacetone
-
Rattus norvegicus
0.118
-
1-phenyl-1,2-propanedione cofactor NADH Rattus norvegicus
0.14
-
propiophenone
-
Rattus norvegicus
0.18
-
menadione
-
Rattus norvegicus
0.43
-
p-nitrobenzaldehyde
-
Rattus norvegicus
0.59
-
Phenylglyoxal
-
Rattus norvegicus
0.75
-
p-quinone
-
Rattus norvegicus
1.02
-
diacetyl cosubstrate NADH Rattus norvegicus
1.1
-
acetophenone
-
Rattus norvegicus
4.4
-
methylglyoxal
-
Rattus norvegicus
5.19
-
2,4-Pentanedione
-
Rattus norvegicus
29
-
acetoin
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus
-
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ enzyme also reduces carbonyl compounds of non-pteridine derivatives Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phenyl-1,2-propanedione + NADPH
-
Rattus norvegicus ?
-
?
2,4-pentanedione + NADPH
-
Rattus norvegicus ?
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
9,10-phenanthrenequinone + NADP+
-
Rattus norvegicus ?
-
?
acetoin + NADPH
-
Rattus norvegicus ?
-
?
acetophenone + NADPH
-
Rattus norvegicus ?
-
?
benzil + NADPH
-
Rattus norvegicus ?
-
?
benzylacetone + NADPH
-
Rattus norvegicus ?
-
?
diacetyl + NADPH
-
Rattus norvegicus ?
-
?
menadione + NADPH
-
Rattus norvegicus ?
-
?
methylglyoxal + NADPH
-
Rattus norvegicus ?
-
?
additional information enzyme is quite similar to general aldo-keto reductases, especially to carbonyl reductase Rattus norvegicus ?
-
?
p-nitrobenzaldehyde + NADPH
-
Rattus norvegicus p-nitrobenzyl alcohol + NADP+
-
?
p-quinone + NADPH
-
Rattus norvegicus ?
-
?
phenylglyoxal + NADPH
-
Rattus norvegicus ?
-
?
propiophenone + NADPH
-
Rattus norvegicus ?
-
?

Cofactor

Cofactor Comment Organism Structure
additional information the enzyme does not contain flavin Rattus norvegicus
NADPH
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00009
-
IC50 0.00009 mM Rattus norvegicus Hg2+
0.0006
-
IC50 0.0006 mM Rattus norvegicus dicoumarol
0.0006
-
IC50 0.0006 mM Rattus norvegicus N-acetylserotonin
0.03
-
IC50 0.03 mM Rattus norvegicus Ethacrynic acid
0.03
-
IC50 0.03 mM Rattus norvegicus 6-Carboxypterin
0.06
-
IC50 0.06 mM Rattus norvegicus indomethacin
0.06
-
IC50 0.06 mM Rattus norvegicus rutin
0.1
-
IC50 0.1 mM Rattus norvegicus Cd2+
0.3
-
IC50 0.3 mM, pH 6.4 Rattus norvegicus propionic acid
0.4
-
IC50 0.4 mM Rattus norvegicus Zn2+
0.6
-
slight, IC50 0.6 mM Rattus norvegicus Phenobarbital
1
-
slight, IC50 1 mM Rattus norvegicus pyrazole
5
-
slight, IC50 5 mM Rattus norvegicus alpha-ketoglutarate