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Literature summary for 1.1.1.149 extracted from
- Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney (2007), J. Steroid Biochem. Mol. Biol., 107, 120-126.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| apigenin | inhibitory effect on hepatic NADPH-dependent activity in decreasing order: fisetin > apigenin > naringenin > quercetin | Mus musculus |  |
| Bromophenol blue | little effect on hepatic NADPH-dependent 20alpha-hydroxysteroid dehydrogenase, moderate inhibitor of hepatic NADH-dependent 20alpha-hydroxysteroid dehydrogenase activity | Mus musculus | |
| fisetin | inhibitory effect on hepatic NADPH-dependent activity in decreasing order: fisetin > apigenin > naringenin > quercetin | Mus musculus | |
| naringenin | inhibitory effect on hepatic NADPH-dependent activity in decreasing order: fisetin > apigenin > naringenin > quercetin | Mus musculus | |
| quercetin | inhibitory effect on hepatic NADPH-dependent activity in decreasing order: fisetin > apigenin > naringenin > quercetin | Mus musculus | |
| Sulfobromophthalein | little effect on hepatic NADPH-dependent 20alpha-hydroxysteroid dehydrogenase, potent inhibitor of hepatic NADH-dependent 20alpha-hydroxysteroid dehydrogenase activity | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | the enzyme catalyzing renal NADPH-dependent 20alpha-hydroxysteroid dehydrogenase activity is distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase activities | Mus musculus | - |
| liver | the enzyme catalyzing renal NADPH-dependent 20alpha-hydroxysteroid dehydrogenase activity is distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase activities | Mus musculus | - |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
renal NADH-dependent 20alpha-hydroxysteroid dehydrogenase | Mus musculus |
| 6.5 | - |
hepatic NADPH-dependent 20alpha-hydroxysteroid dehydrogenase | Mus musculus |
| 7.4 | - |
hepatic NADH-dependent 20alpha-hydroxysteroid dehydrogenase | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Mus musculus | |
| NADPH | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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