General Stability | Organism |
---|---|
sensitive to molecular oxygen | Eubacterium sp. |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Eubacterium sp. |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
NADP+ | - |
Eubacterium sp. | |
0.005 | - |
NADPH | - |
Eubacterium sp. | |
0.031 | - |
4-androsten-3,17-dione | - |
Eubacterium sp. | |
0.07 | - |
Epitestosterone | - |
Eubacterium sp. |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Eubacterium sp. | |
Zn2+ | - |
Eubacterium sp. |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
4 * 42000, SDS-PAGE | Eubacterium sp. |
160000 | - |
gel filtration | Eubacterium sp. |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Eubacterium sp. | - |
inducible by growth on androstenedione and cholic acid, not deoxycholic acid | - |
Eubacterium sp. | - |
VPI 12708 | - |
Eubacterium sp. VPI 12708 | - |
VPI 12708 | - |
Purification (Comment) | Organism |
---|---|
- |
Eubacterium sp. |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.8 | - |
oxidation of 17alpha-hydroxy-4-androsten-3-one | Eubacterium sp. |
3.25 | - |
reduction of 4-androsten-3,17-dione | Eubacterium sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-estradiol + NAD(P)+ | - |
Eubacterium sp. | estrone + NAD(P)H | - |
r | |
17alpha-estradiol + NAD(P)+ | - |
Eubacterium sp. VPI 12708 | estrone + NAD(P)H | - |
r | |
17alpha-hydroxy-4-androsten-3-one + NADP+ | epitestosterone | Eubacterium sp. | 4-androsten-3,17-dione + NADPH | - |
r | |
17alpha-hydroxy-4-androsten-3-one + NADP+ | epitestosterone | Eubacterium sp. VPI 12708 | 4-androsten-3,17-dione + NADPH | - |
r |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 42000, SDS-PAGE | Eubacterium sp. |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxysteroid dehydrogenase | - |
Eubacterium sp. |
More | N-terminal sequence comparison of several enzymes: 17alpha-hydroxysteroid dehydrogenase belongs to the disulfide oxidoreductase family, subfamily dihydrolipoamide dehydrogenases | Eubacterium sp. |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 7 | reduction of 4-androsten-3,17-dione | Eubacterium sp. |
6.5 | - |
oxidation of 17alpha-hydroxy-4-androsten-3-one | Eubacterium sp. |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | highly specific for | Eubacterium sp. |