Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3S)-1-(3-chloro-2-methylbenzene-1-sulfonyl)-N-cyclohexylpiperidine-3-carboxamide | INCB-13739, selective inhibitor for isoform 11beta-HSD1 | Homo sapiens | |
4-(cyclopentylsulfanyl)-3-[[1-(2,4-dichlorobenzamido)cyclopropyl]methoxy]-N-[(1R,2s,3S,5s,7s)-5-hydroxyadamantan-2-yl]-1,2-oxazole-5-carboxamide | - |
Homo sapiens | |
AZD-4017 | selective inhibitor for isoform 11beta-HSD1 | Homo sapiens | |
INCB-13739 | selective inhibitor for isoform 11beta-HSD1 | Homo sapiens | |
UE2343 | selective inhibitor for isoform 11beta-HSD1 | Homo sapiens | |
[(1R,3r,5S)-3-hydroxy-3-(pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-8-yl][5-(1H-pyrazol-4-yl)thiophen-3-yl]methanone | selective inhibitor for isoform 11beta-HSD1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADP+ | Homo sapiens | - |
11-dehydrocorticosterone + NADPH + H+ | - |
? | |
cortisol + NADP+ | Homo sapiens | - |
cortisone + NADPH + H+ | - |
r | |
cortisone + NADPH + H+ | Homo sapiens | preferred direction of reaction | cortisol + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
corticosterone + NADP+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADPH + H+ | - |
? | |
cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH + H+ | - |
r | |
cortisone + NADPH + H+ | preferred direction of reaction | Homo sapiens | cortisol + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |