Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | Homo sapiens | the reaction is catalyzed by isoform 11beta-HSD2 | cortisone + NADH + H+ | - |
? | |
cortisone + NADPH + H+ | Homo sapiens | the reaction is catalyzed by isoform 11beta-HSD1 | cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Homo sapiens | P80365 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | colonic tissue from inflammatory bowel disease patients and healthy controls | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | the reaction is catalyzed by isoform 11beta-HSD2 | Homo sapiens | cortisone + NADH + H+ | - |
? | |
cortisone + NADPH + H+ | the reaction is catalyzed by isoform 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | isoform | Homo sapiens |
11beta-HSD2 | isoform | Homo sapiens |
11beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | isoform 11beta-HSD2 expression is downregulated in patients with inflammatory bowel disease compared with controls | down |
Homo sapiens | isoform 11beta-HSD1 expression does not vary in patients with inflammatory bowel disease compared with controls | additional information |