Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.146 extracted from

  • Hussey, M.; Holleran, G.; Smith, S.; Sherlock, M.; McNamara, D.
    The role and regulation of the 11 beta-hydroxysteroid dehydrogenase enzyme system in patients with inflammatory bowel disease (2017), Digest. Dis. Sci., 62, 3385-3390 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NAD+ Homo sapiens the reaction is catalyzed by isoform 11beta-HSD2 cortisone + NADH + H+
-
?
cortisone + NADPH + H+ Homo sapiens the reaction is catalyzed by isoform 11beta-HSD1 cortisol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845
-
-
Homo sapiens P80365
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon colonic tissue from inflammatory bowel disease patients and healthy controls Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+ the reaction is catalyzed by isoform 11beta-HSD2 Homo sapiens cortisone + NADH + H+
-
?
cortisone + NADPH + H+ the reaction is catalyzed by isoform 11beta-HSD1 Homo sapiens cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1 isoform Homo sapiens
11beta-HSD2 isoform Homo sapiens
11beta-hydroxysteroid dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADPH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform 11beta-HSD2 expression is downregulated in patients with inflammatory bowel disease compared with controls down
Homo sapiens isoform 11beta-HSD1 expression does not vary in patients with inflammatory bowel disease compared with controls additional information