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Literature summary for 1.1.1.146 extracted from

  • Cirillo, N.; Morgan, D.J.; Pedicillo, M.C.; Celentano, A.; Lo Muzio, L.; McCullough, M.J.; Prime, S.S.
    Characterisation of the cancer-associated glucocorticoid system key role of 11beta-hydroxysteroid dehydrogenase type 2 (2017), Br. J. Cancer, 117, 984-993 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.146

Inhibitors

Inhibitors Comment Organism Structure
18beta-glycyrrhetinic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NADP+ Homo sapiens
-
 cortisone + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P80365
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
 Homo sapiens
-
HaCaT cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
HUP-T3 cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
melanoma cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
RT-4 cell
-
 Homo sapiens
-
skin squamous cell carcinoma cell
-
 Homo sapiens
-
SW-620 cell
-
 Homo sapiens
-
SWH-80 cell
-
 Homo sapiens
-
T-24 cell
-
 Homo sapiens
-
VCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADP+
-
 Homo sapiens cortisone + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
11beta-HSD2
-
 Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression of isoform 11beta-HSD2 is dysregulated in malignant cells down