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Literature summary for 1.1.1.146 extracted from
- Cloning, expression and enzyme activity analysis of testicular 11beta-hydroxysteroid dehydrogenase during seasonal cycle and after hCG induction in air-breathing catfish Clarias gariepinus (2010), J. Steroid Biochem. Mol. Biol., 120, 1-10.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in COS-7 cell | Clarias gariepinus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000056 | - |
11beta-hydroxytestosterone | pH 7.4, 37°C, microsomal assay | Clarias gariepinus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11beta-hydroxytestosterone + NAD+ | Clarias gariepinus | - |
11-oxotestosterone + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clarias gariepinus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gill | prominent expression in testis, anterior kidney, liver and gills | Clarias gariepinus | - |
| kidney | prominent expression in testis, anterior kidney, liver and gills | Clarias gariepinus | - |
| liver | prominent expression in testis, anterior kidney, liver and gills | Clarias gariepinus | - |
| testis | prominent expression in testis, anterior kidney, liver and gills. Expression of isoform 11beta-HSD2 in testis and serum levels of 11-ketotestosterone are high in the prespawning phase | Clarias gariepinus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11beta-hydroxytestosterone + NAD+ | - |
Clarias gariepinus | 11-oxotestosterone + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD2 | - |
Clarias gariepinus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Clarias gariepinus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Clarias gariepinus | administration of human chorionic gonadotropin during prespawning and resting phases reveals initial rise in 11beta-HSD2 transcript at 4 h followed by gradual increase at 8 h, 12 h and peaking at 24 h, only in testis of prespawning phase | up |
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