Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycyrrhetinic acid | 11beta-HSD1 shows 21% residual activity at 0.01 mM, 11beta-HSD2 shows 16% residual activity at 0.01 mM | Homo sapiens | |
additional information | leaf extracts of Eriobotrya japonica preferentially inhibit 11beta-HSD1 over 11beta-HSD2, extracts of roasted but not native coffee beans preferentially inhibit 11beta-HSD1 over 11beta-HSD2 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADP+ | the reaction is catalysed by 11beta-HSD2 | Homo sapiens | cortisone + NADPH | - |
? | |
cortisone + NADPH + H+ | reaction is catalysed by 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-HSD2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |