Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2,3-dihydrospiro[indene-1,3'-piperidine] | - |
Homo sapiens | |
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2,3-dihydrospiro[indene-1,3'-pyrrolidine] | - |
Homo sapiens | |
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-3,4-dihydro-2H-spiro[naphthalene-1,3'-pyrrolidine] | - |
Homo sapiens | |
1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]spiro[indene-1,4'-piperidine] | - |
Homo sapiens | |
2-(2-methyl-2-phenylpropanoyl)-2-azaspiro[4.5]decane | - |
Homo sapiens | |
2-[(1-phenylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane | - |
Homo sapiens | |
2-[(1-pyridin-2-ylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane | - |
Homo sapiens | |
2-[(1-pyridin-4-ylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane | - |
Homo sapiens | |
2-[(4-chlorophenyl)acetyl]-2-azaspiro[4.5]decane | - |
Homo sapiens | |
2-[(4-fluorophenyl)acetyl]-2-azaspiro[4.5]decane | - |
Homo sapiens | |
2-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2-azaspiro[4.5]decane | - |
Homo sapiens | |
2-[[1-(4-fluorophenyl)cyclopropyl]carbonyl]-2-azaspiro[4.5]decane | - |
Homo sapiens | |
6-fluoro-4'-[(1-phenylcyclopropyl)methyl]spiro[chromene-2,1'-cyclohexan]-4(3H)-one | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid-dehydrogenase type I | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000005 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-[(1-phenylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane | |
0.0000015 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-(2-methyl-2-phenylpropanoyl)-2-azaspiro[4.5]decane | |
0.000003 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-[[1-(4-fluorophenyl)cyclopropyl]carbonyl]-2-azaspiro[4.5]decane | |
0.000006 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2-azaspiro[4.5]decane | |
0.000022 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-3,4-dihydro-2H-spiro[naphthalene-1,3'-pyrrolidine] | |
0.000025 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2,3-dihydrospiro[indene-1,3'-pyrrolidine] | |
0.000092 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-[(1-pyridin-2-ylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane | |
0.000094 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]-2,3-dihydrospiro[indene-1,3'-piperidine] | |
0.000252 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-[(1-pyridin-4-ylcyclopropyl)carbonyl]-2-azaspiro[4.5]decane | |
0.00045 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-[(4-chlorophenyl)acetyl]-2-azaspiro[4.5]decane | |
0.00141 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 2-[(4-fluorophenyl)acetyl]-2-azaspiro[4.5]decane | |
0.0021 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 1'-[[1-(4-chlorophenyl)cyclopropyl]carbonyl]spiro[indene-1,4'-piperidine] | |
0.0025 | - |
in 30 mM HEPES buffer, pH 7.4, at 37°C | Homo sapiens | 6-fluoro-4'-[(1-phenylcyclopropyl)methyl]spiro[chromene-2,1'-cyclohexan]-4(3H)-one |