Literature summary for 1.1.1.146 extracted from

Nashev, L.G.; Chandsawangbhuwana, C.; Balazs, Z.; Atanasov, A.G.; Dick, B.; Frey, F.J.; Baker, M.E.; Odermatt, A.
Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids (2007), PLoS ONE, 2, e561.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell of 11beta-hydroxysteroid dehydrogenase alone or together with hexose-6-phosphate dehydrogenase	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
analysis of substratebinding by threedimensional modeling. There are favorable interactions between the C7-hydroxyl group of substrate and the catalytic site when the A ring of substrate is oriented towards the interior of the enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-ketodehydroepiandrosterone + 2 NADPH + 2 H+	-	Homo sapiens	7alpha-hydroxydehydroepiandrosterone + 7beta-hydroxydehydroepiandrosterone + 2 NADP+	formation of alpha- and beta-product in almost equal amounts. In presence of hexose-6-phosphate dehydrogenase, the 7keto-substrate is almost fully metabolized and the 7beta-product is preferentially formed	?
7alpha-hydroxydehydroepiandrosterone + NADP+	-	Homo sapiens	7beta-hydroxydehydroepiandrosterone + 7-ketodehydroepiandrosterone + NADPH	in presence of hexose-6-phosphate dehydrogenase, less substrate is metabolized and accumulation of 7-ketodehydroepiandrosterone is abolished	?
7beta-hydroxydehydroepiandrosterone + NADP+	-	Homo sapiens	7alpha-hydroxydehydroepiandrosterone + 7-ketodehydroepiandrosterone + NADPH	formation of products in almost equal amounts. In presence of hexose-6-phosphate dehydrogenase, less substrate is metabolized and accumulation of 7-ketodehydroepiandrosterone is abolished	?

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)