Protein Variants | Comment | Organism |
---|---|---|
additional information | a cytoplasmic localized mutant of isozyme 11beta-HSD1 catalyzes the oxoreduction of cortisone, but not of 7-oxocholesterol | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | luminal orientation, physiological relevance of the membrane topology of 11beta-HSD1 | Homo sapiens | 5789 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 | cortisol + NADP+ | - |
? | |
additional information | Homo sapiens | isozyme 11beta-HSD1 is essential for local activation of glucocorticoid receptors, compartimentalization is important for its regulation by hexose-6-phosphate dehydrogenase, metabolic regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | isozyme 11beta-HSD1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-oxocholesterol + NADPH + H+ | isozyme 11beta-HSD1, stereospecific reaction | Homo sapiens | 7beta-hydroxycholesterol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? | |
additional information | isozyme 11beta-HSD1 is essential for local activation of glucocorticoid receptors, compartimentalization is important for its regulation by hexose-6-phosphate dehydrogenase, metabolic regulation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |