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Literature summary for 1.1.1.146 extracted from

  • Miguet, L.; Zhang, Z.; Barbier, M.; Grigorov, M.G.
    Comparison of a homology model and the crystallographic structure of human 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) in a structure-based identification of inhibitors (2006), J. Comput. Aided Mol. Des., 20, 67-81.
    View publication on PubMed
Search for more literature for 1.1.1.146

Inhibitors

Inhibitors Comment Organism Structure
1-piperidinecarboxylic acid
-
 Homo sapiens
11-ketotestosterone
-
 Homo sapiens
2'-hydroxyflavanone
-
 Homo sapiens
4'-hydroxyflavanone
-
 Homo sapiens
abietic acid weak inhibition Homo sapiens
benzenesulfonamide
-
 Homo sapiens
BVT-14225
-
 Homo sapiens
BVT-2733
-
 Homo sapiens
chenodeoxycholic acid
-
 Homo sapiens
Cyclobutanone
-
 Homo sapiens
ethanone
-
 Homo sapiens
flavanone
-
 Homo sapiens
indinavir
-
 Homo sapiens
methyl {(1S,2S)-3-oxo-2-[(2Z)-pent-2-en-1-yl]cyclopentyl}acetate weak inhibition Homo sapiens
additional information no inhibition by DETC, flavone, and bisphenol A, molecular docking and modeling of enzyme-inhibitor interactions the model can discriminate between known isozyme 11beta-HSD1 inhibitors or substrates and non-inhibitors, inhibitroy binding mode, overview Homo sapiens
NSC 112288
-
 Homo sapiens
NSC 56412
-
 Homo sapiens
NSC 75617
-
 Homo sapiens
resorcinol weak inhibition Homo sapiens
rosiglitazone
-
 Homo sapiens
saquinavir
-
 Homo sapiens
TZD 2
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens isozyme 11beta-HSD1 cortisol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme 11betaHSD1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
15-deoxy-D12,14-prostaglandin J2 + NADPH isozyme 11beta-HSD1 Homo sapiens ?
-
 ?
cortisone + NADPH + H+ isozyme 11beta-HSD1 Homo sapiens cortisol + NADP+
-
 ?

Subunits

Subunits Comment Organism
More homology modeling and analysis of three-dimensional structure models from crystal structures, model validation, detailed overview Homo sapiens

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
11betaHSD1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens