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Literature summary for 1.1.1.146 extracted from
- Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1 (2003), Chem. Biol. Interact., 143-144, 459-468.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.79 | - |
(+)-11-dihydrooracin | 37°C, pH 10.8-11.0 | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34000 | - |
2 * 34000, SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| octyl-Sepharose, Mono Q-sepharose, Red Sepharose A | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (+)-11-dihydrooracin + NADP+ | - |
Mus musculus | ? | - |
r |  |
| oracin + NADPH + H+ | trivial name oracin, anticancer drug | Mus musculus | 11-dihydrooracin + NADP+ | 93% (+)-11-dihydrooracin | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 34000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD | - |
Mus musculus |
| 11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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