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Literature summary for 1.1.1.146 extracted from

  • Ferrari, P.; Smith, R.E.; Funder, J.W.; Krozowski, Z.S.
    Substrate and inhibitor specificity of the clones human 11beta-hydroxysteroid dehydrogenase type 2 isoform (1996), Am. J. Physiol., 270, E900-904.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
11-deoxycorticosterone
-
Homo sapiens
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Homo sapiens
progesterone
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ Homo sapiens i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoenzymes type 1 and type 2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ i.e. corticosterone, significant higher rate of conversion for 11-beta-HSD2 than for 11-beta-HSD1 Homo sapiens 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
-
ir
dexamethasone + NADP+ isoform 11-beta-HSD2 shows significantly higher rate of conversion than isoform 11-betaHSD1 Homo sapiens 11-dehydromethasone + NADPH
-
ir

Synonyms

Synonyms Comment Organism
11-beta-HSD1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens