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Literature summary for 1.1.1.145 extracted from

  • Hu, G.X.; Zhou, H.Y.; Li, X.W.; Chen, B.B.; Xiao, Y.C.; Lian, Q.Q.; Liang, G.; Kim, H.H.; Zheng, Z.Q.; Hardy, D.O.; Ge, R.S.
    The (+)- and (-)-gossypols potently inhibit both 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 in human and rat testes (2009), J. Steroid Biochem. Mol. Biol., 115, 14-19.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+)-gossypol potent inhibitor Homo sapiens
(+)-gossypol potent inhibitor Rattus norvegicus
(-)-gossypol potent inhibitor Homo sapiens
(-)-gossypol potent inhibitor Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Homo sapiens
-
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregnenolone + NAD+
-
Homo sapiens progesterone + NADH + H+
-
?
pregnenolone + NAD+
-
Rattus norvegicus progesterone + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
3beta-HSD
-
Homo sapiens
3beta-HSD
-
Rattus norvegicus
3beta-hydroxysteroid dehydrogenase
-
Homo sapiens
3beta-hydroxysteroid dehydrogenase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00019
-
in PBS buffer, pH 7.2 Rattus norvegicus (+)-gossypol
0.00023
-
in PBS buffer, pH 7.2 Rattus norvegicus (-)-gossypol
0.00277
-
in PBS buffer, pH 7.2 Homo sapiens (-)-gossypol
0.00445
-
in PBS buffer, pH 7.2 Homo sapiens (+)-gossypol