Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E126L | site-directed mutagenesis, functional characterization | Homo sapiens |
H232A | site-directed mutagenesis, functional characterization | Homo sapiens |
N100A | site-directed mutagenesis, functional characterization | Homo sapiens |
N100S | site-directed mutagenesis, functional characterization | Homo sapiens |
N323L | site-directed mutagenesis, functional characterization | Homo sapiens |
S322A | site-directed mutagenesis, functional characterization | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is essential for biosynthesis of all classes of steroid hormones catalyzing the first step of the multienzyme pathway conversion of circulating dehydroepiandrosterone and pregnenolone to active steroid hormones | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14060 | 3beta-HSD1; type 1 isozyme | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a 3beta-hydroxy-DELTA5-steroid + NAD+ = a 3-oxo-DELTA5-steroid + NADH + H+ | substrate binding and active site residues, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is essential for biosynthesis of all classes of steroid hormones catalyzing the first step of the multienzyme pathway conversion of circulating dehydroepiandrosterone and pregnenolone to active steroid hormones | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | three-dimensional structure modeling of enzyme in ternary complex with NAD+ and androstenedione using crystals structures of enzymes from other organisms, substrate binding and active site residue determination, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
3beta-HSD_1 | - |
Homo sapiens |
3beta-hydroxysteroid dehydrogenase/isomerase type 1 | - |
Homo sapiens |
More | the enzyme belongs to the short chain dehydrogenase/reductase family | Homo sapiens |