Cloned (Comment) | Organism |
---|---|
expression in Sf9 cells | Homo sapiens |
expression in Sf9 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D241N | 39% of wild-type activity | Homo sapiens |
D257L | trace activity | Homo sapiens |
D258L | trace activity | Homo sapiens |
D265N | 12% of wild-type activity | Homo sapiens |
D36A/K37R | uses NADP+ as cofactor, no activity with NAD+ | Homo sapiens |
H156Y | 195% of wild-type activity | Homo sapiens |
K158Q | no activity | Homo sapiens |
K273Q | no activity | Homo sapiens |
Y154F | no activity | Homo sapiens |
Y269S | no activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epostane | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0037 | - |
dehydroepiandrosterone | 27°C, pH 7.4 | Homo sapiens | |
0.025 | - |
NAD+ | 27°C, pH 7.4, H156Y mutant | Homo sapiens | |
0.034 | - |
NAD+ | 27°C, pH 7.4 | Homo sapiens | |
0.042 | - |
dehydroepiandrosterone | 27°C, pH 7.4, H156Y mutant | Homo sapiens | |
0.047 | - |
dehydroepiandrosterone | 27°C, pH 7.4 | Homo sapiens | |
0.086 | - |
NAD+ | 27°C, pH 7.4 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
42000 | - |
x * 42000, SDS-PAGE, recombinant 3beta-HSD | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | Homo sapiens | - |
androst-5-en-3,17-dione + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant 3beta-HSD | Homo sapiens |
recombinant 3beta-HSD type 2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
gonad | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androst-5-en-3,17-dione + NADH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 42000, SDS-PAGE, recombinant 3beta-HSD | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
3beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00007 | - |
epostane | 27°C, pH 7.4 | Homo sapiens | |
0.00098 | - |
epostane | 27°C, pH 7.4 | Homo sapiens |