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Literature summary for 1.1.1.141 extracted from

  • Chi, X.; Freeman, B.M.; Tong, M.; Zhao, Y.; Tai, H.H.
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells (2009), Arch. Biochem. Biophys., 487, 139-145.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information flurbiprofen induces 15-PGDH expression in cancer cells, PD98059 and U-0126 elevate 15-PGDH levels very significantly Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
T-98G cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
15-hydroxyprostaglandin + NAD+
-
Homo sapiens 15-oxoprostaglandin + NADH + H+
-
?
prostaglandin E2 + NAD+
-
Homo sapiens 15-ketoprostaglandin E2 + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
15-hydroxyprostaglandin dehydrogenase
-
Homo sapiens
15-PGDH
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens