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Literature summary for 1.1.1.141 extracted from

  • Otani, T.; Yamaguchi, K.; Scherl, E.; Du, B.; Tai, H.H.; Greifer, M.; Petrovic, L.; Daikoku, T.; Dey, S.K.; Subbaramaiah, K.; Dannenberg, A.J.
    Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha (2006), Am. J. Physiol., 290, G361-G368.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient expression in HT29 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information TNF-alpha suppresses the enzyme expression in colonocytes Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH Homo sapiens
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 r
additional information Homo sapiens key enzyme for metabolic inactivation of prostaglandins, enzyme levels are reduced in inflammatory bowel disease involving TNF-alpha ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Homo sapiens
-
colonocyte
-
Homo sapiens
-
HT-29 cell colon cancer cell line Homo sapiens
-
mucosa enzyme activity is reduced in inflamed mucosa Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH
-
Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 r
additional information key enzyme for metabolic inactivation of prostaglandins, enzyme levels are reduced in inflammatory bowel disease involving TNF-alpha Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
15-PGDH
-
Homo sapiens
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens