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Literature summary for 1.1.1.141 extracted from
- Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors (2002), Arch. Biochem. Biophys., 405, 247-251.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-methoxybenzyl-2,4-thiazolidinedione | - |
Homo sapiens |  |
| 4-methoxybenzylidene-2,4-thiazolidinedione | - |
Homo sapiens | |
| 5-[4-((1-methyl)-cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione | - |
Homo sapiens | |
| 5-[4-((1-methyl)-cyclohexylmethoxy)benzyl]-2,4-thiazolidenedione | trivial name ciglitazone | Homo sapiens | |
| 5-[4-(benzoxy)benzylidene]-2,4-thiazolidenedione | - |
Homo sapiens | |
| 5-[4-(cyclohexylbutoxy)benzylidene]-2,4-thiazolidenedione | - |
Homo sapiens | |
| 5-[4-(cyclohexylethoxy)benzylidene]-2,4-thiazolidenedione | - |
Homo sapiens | |
| 5-[4-(cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione | - |
Homo sapiens | |
| 5-[4-(cyclohexyloxy)benzylidene]-2,4-thiazolidenedione | - |
Homo sapiens | |
| 5-[4-(cyclohexylpropoxy)benzylidene]-2,4-thiazolidenedione | - |
Homo sapiens | |
| ciglitazone | - |
Homo sapiens | |
| rosiglitazone | - |
Homo sapiens | |
| troglitazone | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Homo sapiens | - |
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | - |
Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 15-PGDH | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00009 | - |
5-[4-(cyclohexylethoxy)benzylidene]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.00011 | - |
5-[4-(cyclohexylpropoxy)benzylidene]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.00027 | - |
5-[4-(cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.0006 | - |
5-[4-((1-methyl)-cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.0009 | - |
5-[4-(cyclohexyloxy)benzylidene]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.0012 | - |
5-[4-(benzoxy)benzylidene]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.0022 | - |
5-[4-((1-methyl)-cyclohexylmethoxy)benzyl]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.005 | - |
5-[4-(cyclohexylbutoxy)benzylidene]-2,4-thiazolidenedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.017 | - |
4-methoxybenzylidene-2,4-thiazolidinedione | 37°C, pH 7.5 | Homo sapiens | |
| 0.62 | - |
4-methoxybenzyl-2,4-thiazolidinedione | 37°C, pH 7.5 | Homo sapiens | |
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