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Literature summary for 1.1.1.138 extracted from

  • Velez, H.; Glassbrook, N.J.; Daub, M.E.
    Mannitol biosynthesis is required for plant pathogenicity by Alternaria alternata (2008), FEMS Microbiol. Lett., 285, 122-129.
    View publication on PubMed
Search for more literature for 1.1.1.138

Activating Compound

Activating Compound Comment Organism Structure
additional information MtDH transcript increases after treatment with tobacco leaf extract Alternaria alternata
additional information transcript of both MtDH and MPDH start to increase by 30 min after the addition of tobacco extract, reaching 2.5fold to almost 4fold higher by 2 h. No increase in transcript for MtDH and MPDH if cultures are treated with water instead of tobacco leaf extract Alternaria alternata

Protein Variants

Protein Variants Comment Organism
additional information MtDH mutant produces less mannitol than compared to the wild-type. The MtDH/MPDH double mutant does not produce mannitol. Response of the genes in the disruption mutants is similar to that in wild-type. Conidia of mutants are viable and germinated normally. Elevated levels of trehalose in the mutants, suggesting that trehalose may substitute for mannitol as a storage compound for germination. Tobacco inoculation shows no reduction in lesion severity caused by the MtDH mutant as compared with wild-type, whereas the MtDH/MPDH double mutant causes significantly less disease. The double mutant is unaffected in the ability to germinate and produce appressoria on tobacco leaves and elicites a defense response from the host, indicating that it is able to penetrate and infect the host Alternaria alternata

Organism

Organism UniProt Comment Textmining
Alternaria alternata
-
-
-
Alternaria alternata A5
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-mannitol + NAD(P)+
-
 Alternaria alternata D-fructose + NAD(P)H + H+
-
 ?
D-mannitol + NAD(P)+
-
 Alternaria alternata A5 D-fructose + NAD(P)H + H+
-
 ?
D-mannitol + NADP+
-
 Alternaria alternata D-fructose + NADPH + H+
-
 r
D-mannitol + NADP+
-
 Alternaria alternata A5 D-fructose + NADPH + H+
-
 r

Synonyms

Synonyms Comment Organism
MtDH
-
 Alternaria alternata

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Alternaria alternata