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Literature summary for extracted from

  • Roth, S.; Praeg, A.; Wechsler, C.; Marolt, M.; Ferlaino, S.; Luedeke, S.; Sandon, N.; Wetzl, D.; Iding, H.; Wirz, B.; Mueller, M.
    Extended catalytic scope of a well-known enzyme asymmetric reduction of iminium substrates by glucose dehydrogenase (2017), ChemBioChem, 18, 1703-1706 .
    View publication on PubMed


Application Comment Organism
synthesis glucose dehydrogenase is generally used to regenerate the expensive cofactor NADPH by oxidation of D-glucose to gluconolactone Bacillus subtilis


Organism UniProt Comment Textmining
Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + NADP+
Bacillus subtilis D-glucono-1,5-lactone + NADPH + H+
additional information reduction of C=N bonds with good levels of conversion (more than 50%) and excellent enantioselectivity (up to more than 99% enantiomeric excess) by glucose dehydrogenase represents a promiscuous catalytic activity of this enzyme Bacillus subtilis ?