Literature summary for 1.1.1.119 extracted from

Roth, S.; Praeg, A.; Wechsler, C.; Marolt, M.; Ferlaino, S.; Luedeke, S.; Sandon, N.; Wetzl, D.; Iding, H.; Wirz, B.; Mueller, M.
Extended catalytic scope of a well-known enzyme asymmetric reduction of iminium substrates by glucose dehydrogenase (2017), ChemBioChem, 18, 1703-1706 .

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Application

Application	Comment	Organism
synthesis	glucose dehydrogenase is generally used to regenerate the expensive cofactor NADPH by oxidation of D-glucose to gluconolactone	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-glucose + NADP+	-	Bacillus subtilis	D-glucono-1,5-lactone + NADPH + H+	-	?
additional information	reduction of C=N bonds with good levels of conversion (more than 50%) and excellent enantioselectivity (up to more than 99% enantiomeric excess) by glucose dehydrogenase represents a promiscuous catalytic activity of this enzyme	Bacillus subtilis	?	-	-

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Release 2023.1 (January 2023)