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Literature summary for 1.1.1.112 extracted from

  • Hara, A.; Kariya, K.; Nakamura, M.; Nakayama, T.; Saweda, H.
    Isolation of multiple forms of indanol dehydrogenase associated with 17-beta-hydroxysteroid dehydrogenase activity from male rabbit (1986), Arch. Biochem. Biophys., 249, 225-236.
    View publication on PubMed
Search for more literature for 1.1.1.112

Inhibitors

Inhibitors Comment Organism Structure
6alpha-Methylprednisolone 0.1 mM, oxidation of acenaphthenol: 0% inhibition of isozyme 1, 40% inhibition of isozyme 2, 23%,inhibition of isozyme 3, 89% inhibition of isozyme 4, 14% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 18% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 7% inhibition of isozyme 1, 41% inhibition of isozyme 2, 30%,inhibition of isozyme 3, 86% inhibition of isozyme 4, 11% inhibition of isozyme 5, 16% inhibition of isozyme 6 and 20% inhibition of isoenzyme 7 Oryctolagus cuniculus
betamethazone 0.05 mM, oxidation of acenaphthenol: 32% inhibition of isozyme 1, 16% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 95% inhibition of isozyme 4, 27% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 14% inhibition of isozyme 1, 26% inhibition of isozyme 2, 97%,inhibition of isozyme 3, 96% inhibition of isozyme 4, 30% inhibition of isozyme 5, 22% inhibition of isozyme 6 and 6% inhibition of isoenzyme 7 Oryctolagus cuniculus
Dienstrol 0.01 mM, oxidation of acenaphthenol: 27% inhibition of isozyme 1, 84% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 94% inhibition of isozyme 4, 0% inhibition of isozyme 5, 66% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 27% inhibition of isozyme 1, 85% inhibition of isozyme 2, 99%,inhibition of isozyme 3, 97% inhibition of isozyme 4, 0% inhibition of isozyme 5, 51% inhibition of isozyme 6 and 0% inhibition of isoenzyme 7 Oryctolagus cuniculus
diethylstilbestrol 0.01 mM, oxidation of acenaphthenol: 25% inhibition of isozyme 1, 68% inhibition of isozyme 2, 94%,inhibition of isozyme 3, 90% inhibition of isozyme 4, 6% inhibition of isozyme 5, 44% inhibition of isozyme 6 and 44% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 23% inhibition of isozyme 1, 69% inhibition of isozyme 2, 87%,inhibition of isozyme 3, 99% inhibition of isozyme 4, 0% inhibition of isozyme 5, 49% inhibition of isozyme 6 and 47% inhibition of isoenzyme 7 Oryctolagus cuniculus
Flufenamic acid 0.1 mM, oxidation of acenaphthenol: 54% inhibition of isozyme 1, 47% inhibition of isozyme 2, 64%,inhibition of isozyme 3, 60% inhibition of isozyme 4, 50% inhibition of isozyme 5, 57% inhibition of isozyme 6 and 38% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 46% inhibition of isozyme 1, 45% inhibition of isozyme 2, 47%,inhibition of isozyme 3, 49% inhibition of isozyme 4, 58% inhibition of isozyme 5, 46% inhibition of isozyme 6 and 43% inhibition of isoenzyme 7 Oryctolagus cuniculus
Hexestrol 0.01 mM, oxidation of acenaphthenol: 76% inhibition of isozyme 1, 82% inhibition of isozyme 2, 95%,inhibition of isozyme 3, 87% inhibition of isozyme 4, 20% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 72% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 66% inhibition of isozyme 1, 84% inhibition of isozyme 2, 90%,inhibition of isozyme 3, 85% inhibition of isozyme 4, 10% inhibition of isozyme 5, 50% inhibition of isozyme 6 and 77% inhibition of isoenzyme 7 Oryctolagus cuniculus
indomethacin 0.1 mM, oxidation of acenaphthenol: 20% inhibition of isozyme 1, 49% inhibition of isozyme 2, 55%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 64% inhibition of isozyme 5, 59% inhibition of isozyme 6 and 3% inhibition of isoenzyme 7 Oryctolagus cuniculus
Zomepirac 0.1 mM, oxidation of acenaphthenol: 69% inhibition of isozyme 1, 46% inhibition of isozyme 2, 71%,inhibition of isozyme 3, 78% inhibition of isozyme 4, 69% inhibition of isozyme 5, 72% inhibition of isozyme 6 and 56% inhibition of isoenzyme 7, oxidation of 5alpha-androstane-3alpha,17beta-diol: 70% inhibition of isozyme 1, 68% inhibition of isozyme 2, 68%,inhibition of isozyme 3, 56% inhibition of isozyme 4, 68% inhibition of isozyme 5, 71% inhibition of isozyme 6 and 66% inhibition of isoenzyme 7 Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 gel filtration, isoenzyme 2 Oryctolagus cuniculus
31000
-
 gel filtration, isoenzyme 3 Oryctolagus cuniculus
31000
-
 gel filtration, isoenzyme 7 Oryctolagus cuniculus
32000
-
 gel filtration, isoenzyme 1 Oryctolagus cuniculus
33000
-
 gel filtration, isoenzyme 5 Oryctolagus cuniculus
34000
-
 gel filtration, isoenzyme 4 Oryctolagus cuniculus
36000
-
 gel filtration, isoenzyme 6 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate, CM-Sephadex, Sephadex G-1000, DEAE-Sephacel, Blue-Sepharose, hydroxyapatite, DEAE-Sephacel, isoelectric focusing, CM-Sepharose, isoenzymes 1-7 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13
-
 isoenzyme 5, substrate 1-acenaphthenol Oryctolagus cuniculus
2.02
-
 isoenzyme 1, substrate 1-acenaphthenol Oryctolagus cuniculus
2.93
-
 isoenzyme 4, substrate 1-acenaphthenol Oryctolagus cuniculus
4.03
-
 isoenzyme 2, substrate 1-acenaphthenol Oryctolagus cuniculus
4.09
-
 isoenzyme 3, substrate 1-acenaphthenol Oryctolagus cuniculus
4.33
-
 isoenzyme 6, substrate 1-acenaphthenol Oryctolagus cuniculus
7.77
-
 isoenzyme 7, substrate 1-acenaphthenol Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2,3,4-tetrahydro-1-naphthol + NAD(P)+ isoenzymes 1-7 Oryctolagus cuniculus 1,2,3,4-tetrahydro-1-naphthone + NAD(P)H
-
 ?
1-acenaphthenol + NAD(P)+ isoenzymes 1-7 Oryctolagus cuniculus 1-acenaphthenone + NAD(P)H
-
 ?
1-acenaphthenol + NAD(P)+ four times higher activity compared to indan-1-ol Oryctolagus cuniculus 1-acenaphthenone + NAD(P)H
-
 ?
19-nortestosterone + NAD(P)+ isoenzymes 3-5 Oryctolagus cuniculus estr-4-en-3,17-dione + NADH
-
 ?
4-benzoylpyridine + NADH isoenzymes 1,2,3,5,6 Oryctolagus cuniculus 4-(benzyl alcohol)pyridine + NAD+
-
 ?
4-nitroacetophenone + NADH isoenzymes 1,2,3,5 Oryctolagus cuniculus (1-hydroxyethyl)-4-nitro-benzene + NAD+
-
 ?
4-nitrobenzaldehyde + NAD(P)H isoenzymes 1-7 Oryctolagus cuniculus 4-nitrobenzyl alcohol + NAD(P)+
-
 ?
5alpha-androstan-3-beta,17beta-diol + NAD+ isoenzymes 2-6 Oryctolagus cuniculus 5alpha-androstan-3beta-ol-17-one + NADH
-
 ?
5alpha-androstan-3alpha,17beta-diol + NAD+ isoenzymes 1-6 Oryctolagus cuniculus 5alpha-androstan-3alpha-ol-17-one + NADH
-
 ?
5alpha-androstan-3alpha-ol-17-one + NAD+ isoenzymes 4-5 Oryctolagus cuniculus 5alpha-androstan-3,17-dione + NADH + H+
-
 ?
5alpha-androstan-3alpha-ol-17-one + NADH isoenzymes 2,3,4,6 Oryctolagus cuniculus 5alpha-androstan-3alpha,17alpha-diol + NAD+
-
 ?
5alpha-androstan-3beta-ol-17-one + NAD+ isoenzymes 2-3 Oryctolagus cuniculus 5alpha-androstan-3,17-dione + NADH + H+
-
 ?
5alpha-dihydrotestosterone + NAD(P)+ isoenzymes 2-6 Oryctolagus cuniculus 5alpha-dihydro-17-oxo-testosterone + NADH
-
 ?
5alpha-dihydrotestosterone + NAD+ isoenzymes 1-6 Oryctolagus cuniculus 5alpha-17-oxo-dihydrotestosterone + NADH + H+
-
 ?
5beta-androstan-3alpha,17beta-diol + NAD+ isoenzymes 1-7 Oryctolagus cuniculus 5beta-androstan-3alpha-ol-17-one + NADH
-
 ?
5beta-androstan-3alpha-ol-17-one + NAD+ isoenzymes 3-4 Oryctolagus cuniculus 5beta-androstan-3,17-dione + NADH
-
 ?
5beta-androstan-3alpha-ol-17-one + NADH isoenzymes 2,3,4,6,7 Oryctolagus cuniculus 5beta-androstan-3alpha,17alpha-diol + NAD+
-
 ?
5beta-androstan-3beta,17beta-diol + NAD+ isoenzymes 2-6 Oryctolagus cuniculus 5alpha-androstan-3beta-ol-17-one + NADH
-
 ?
5beta-androstan-3beta-ol-17-one + NAD+ isoenzyme 5 Oryctolagus cuniculus 5beta-androstan-3,17-dione + NADH
-
 ?
5beta-dihydrotestosterone + NAD(P)+ isoenzymes 2-6 Oryctolagus cuniculus 5beta-dihydro-17-oxo-testosterone + NADH
-
 ?
5beta-dihydrotestosterone + NAD+ isoenzymes 1-6 Oryctolagus cuniculus 5beta-17-oxo-dihydrotestosterone + NADH + H+
-
 ?
benzene dihydrodiol + NAD(P)+ isoenzymes 1-7 Oryctolagus cuniculus o-benzoquinone + NAD(P)H
-
 ?
cyclohex-2-en-1-ol + NAD(P)+ isoenzymes 1-7 Oryctolagus cuniculus cyclohex-2-en-1-one + NAD(P)H
-
 ?
cyclohexanol + NAD(P)+ isoenzymes 1-7 Oryctolagus cuniculus cyclohexanone + NAD(P)H
-
 ?
DL-glyceraldehyde + NADH isoenzymes 1-6 Oryctolagus cuniculus glycerol + NAD+
-
 ?
indan-(S)-1-ol + NAD(P)+ isoenzymes 1-7 Oryctolagus cuniculus indan-1-one + NAD(P)H
-
 ?
indan-2-ol + NAD(P)+ isoenzymes 1,2,3,4,6 Oryctolagus cuniculus indan-2-one + NAD(P)H
-
 ?
pyridine-4-aldehyde + NADH isoenzymes 1-7 Oryctolagus cuniculus pyridine-4-alcohol + NAD+
-
 ?
testosterone + NAD(P)+
-
 Oryctolagus cuniculus androst-4-ene-3,17-dione + NADH + H+ isoenzymes 3-6 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 10 isoenzyme 5 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Oryctolagus cuniculus
NADP+
-
 Oryctolagus cuniculus