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Literature summary for 1.1.1.103 extracted from

  • Chen, Y.W.; Dekker, E.E.; Somerville, R.L.
    Functional analysis of E. coli threonine dehydrogenase by means of mutant isolation and characterization (1995), Biochim. Biophys. Acta, 1253, 208-214.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
C38S 1 cysteine residue per subunit is essential for catalytic activity and Mn2+ binding Escherichia coli K-12

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ enzyme contains 1 Zn2+ atom per subunit Escherichia coli K-12

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-threonine + NAD+ Escherichia coli K-12
-
 (2S)-2-amino-3-oxobutanoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli K-12
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonine + NAD+
-
 Escherichia coli K-12 (2S)-2-amino-3-oxobutanoate + NADH + H+
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.3
-
-
 Escherichia coli K-12

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Escherichia coli K-12