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Literature summary for 1.1.1.101 extracted from

  • Webber, K.O.; Datta, N.S.; Hajra, A.K.
    Properties of the enzymes catalyzing the biosynthesis of lysophosphatidate and its ether analog in cultured fibroblasts from Zellweger syndrome patients and normal controls (1987), Arch. Biochem. Biophys., 254, 611-620.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0051
-
NADPH skin fibroblasts, normal cells Homo sapiens
0.0054
-
NADPH skin Zellwenger syndrome fibroblasts Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyldihydroxyacetone phosphate + NADPH Homo sapiens acyldihydroxyacetone phosphate pathway 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
alkyldihydroxyacetone phosphate + NADPH + H+ Homo sapiens acyldihydroxyacetone phosphate pathway 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast Zellweger syndrome cell lines GM0228 and GM4340 and normal control cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyldihydroxyacetone phosphate + NADPH
-
Homo sapiens 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
acyldihydroxyacetone phosphate + NADPH acyldihydroxyacetone phosphate pathway Homo sapiens 1-acyl-sn-glycerol 3-phosphate + NADP+
-
?
alkyldihydroxyacetone phosphate + NADPH + H+
-
Homo sapiens 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
?
alkyldihydroxyacetone phosphate + NADPH + H+ acyldihydroxyacetone phosphate pathway Homo sapiens 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
?
hexadecyldihydroxyacetone phosphate + NADPH
-
Homo sapiens 1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
?

Temperature Stability [┬░C]

Temperature Stability Minimum [┬░C] Temperature Stability Maximum [┬░C] Comment Organism
50
-
t1/2: 15 min, control fibroblasts, t1/2: 20 min, Zellweger syndrome fibroblasts Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates Homo sapiens