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Literature summary for 1.1.1.100 extracted from

  • Liu, C.; Qi, J.; Shan, B.; Ma, Y.
    Tachyplesin causes membrane instability that kills multidrug-resistant bacteria by inhibiting the 3-ketoacyl carrier protein reductase FabG (2018), Front. Microbiol., 9, 825 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.100

Cloned(Commentary)

Cloned (Comment) Organism
C-terminal His-tagged FabG from Staphylococcus aureus is cloned into the NcoI and XhoI cloning sites of the vector pET28a, expressed in BL21 DE3 Escherichia coli Staphylococcus aureus
N-terminal His-tagged FabG from Escherichia coli is cloned into the NcoI and XhoI cloning sites of the vector pET28a, expressed in BL21 DE3 Escherichia coli Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
tachyplesin
-
 Acinetobacter baumannii
tachyplesin
-
 Escherichia coli
tachyplesin
-
 Klebsiella pneumoniae
tachyplesin
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii
-
-
-
Acinetobacter baumannii 1408
-
-
-
Escherichia coli P0AEK2
-
-
Escherichia coli K12 P0AEK2
-
-
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae 5
-
-
-
Staphylococcus aureus Q2FZ53
-
-
Staphylococcus aureus NCTC 8325 Q2FZ53
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Klebsiella pneumoniae
-
 Escherichia coli
-
 Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetoacetyl-CoA + NADPH + H+
-
 Klebsiella pneumoniae 3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Acinetobacter baumannii 3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Escherichia coli 3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Staphylococcus aureus 3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Staphylococcus aureus NCTC 8325 3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Klebsiella pneumoniae 5 3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Escherichia coli K12 3-hydroxybutyryl-CoA + NADP+
-
 ?
acetoacetyl-CoA + NADPH + H+
-
 Acinetobacter baumannii 1408 3-hydroxybutyryl-CoA + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
3-ketoacyl-acyl carrier protein reductase
-
 Klebsiella pneumoniae
3-ketoacyl-acyl carrier protein reductase
-
 Acinetobacter baumannii
3-ketoacyl-acyl carrier protein reductase
-
 Escherichia coli
3-ketoacyl-acyl carrier protein reductase
-
 Staphylococcus aureus
FabG
-
 Klebsiella pneumoniae
FabG
-
 Acinetobacter baumannii
FabG
-
 Escherichia coli
FabG
-
 Staphylococcus aureus

Expression

Organism Comment Expression
Klebsiella pneumoniae elevated expression detected after tachyplesin III treatment up
Acinetobacter baumannii elevated expression detected after tachyplesin III treatment up
Escherichia coli elevated expression detected after tachyplesin III treatment up
Staphylococcus aureus elevated expression detected after tachyplesin III treatment up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the unsaturated fatty acid biosynthetic pathway Klebsiella pneumoniae
metabolism the enzyme is involved in the unsaturated fatty acid biosynthetic pathway Acinetobacter baumannii
metabolism the enzyme is involved in the unsaturated fatty acid biosynthetic pathway Escherichia coli
metabolism the enzyme is involved in the unsaturated fatty acid biosynthetic pathway Staphylococcus aureus