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Literature summary for 1.1.1.100 extracted from

  • Han, J.; Lu, Q.; Zhou, L.; Liu, H.; Xiang, H.
    Identification of the polyhydroxyalkanoate (PHA)-specific acetoacetyl coenzyme A reductase among multiple FabG paralogs in Haloarcula hispanica and reconstruction of the PHA biosynthetic pathway in Haloferax volcanii (2009), Appl. Environ. Microbiol., 75, 6168-6175.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
heterologous coexpression of the polyhydroxyalkanoate synthase genes phaEC together with fabG1 in Haloferax volcanii Haloarcula hispanica
heterologous coexpression of the polyhydroxyalkanoate synthase genes phaEC together with Haloarcula hispanica fabG1 reconstructs the polyhydroxyalkanoate biosynthetic pathway Haloferax volcanii

Organism

Organism UniProt Comment Textmining
Haloarcula hispanica
-
-
-
Haloarcula hispanica AS2049
-
-
-
Haloferax volcanii
-
-
-

Synonyms

Synonyms Comment Organism
beta-ketoacyl-ACP reductase
-
Haloferax volcanii
beta-ketoacyl-ACP reductase
-
Haloarcula hispanica
FabG1
-
Haloferax volcanii
FabG1
-
Haloarcula hispanica
PHA-specific acetoacetyl-CoA reductase
-
Haloferax volcanii
PHA-specific acetoacetyl-CoA reductase
-
Haloarcula hispanica
PhaB
-
Haloferax volcanii
PhaB
-
Haloarcula hispanica
polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase
-
Haloferax volcanii
polyhydroxyalkanoate-specific acetoacetyl coenzyme A reductase
-
Haloarcula hispanica

Cofactor

Cofactor Comment Organism Structure
NADPH dependent on Haloarcula hispanica

General Information

General Information Comment Organism
malfunction DELTAfabG1 cells lose the ability to accumulate poly(3-hydroxybutyrate-co-3-hydroxyvalerate). When the DELTAfabG1 strain is transformed with the fabG1 expression plasmid pWLG1, the capability of polyhydroxyalkanoate accumulation is restored. When the fabG1 gene is disrupted or knocked out, the NADPH-dependent activity of acetoacetyl-CoA reductase in the mutant, the DELTAfabG1 or fabG1-1 strain, is greatly decreased Haloarcula hispanica
malfunction polyhydroxyalkanoate-defective haloarchaeon Haloferax volcanii
physiological function FabG1 has the function of supplying precursors for polyhydroxyalkanoate biosynthesis Haloarcula hispanica