Crystallization (Comment) | Organism |
---|---|
structure determination and similarities within short-chain alcohol dehydrogenase family, catalytic mechanism | Brassica napus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-oxoacyl-[acyl-carrier protein] + NADPH | Escherichia coli | - |
(3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
? | |
3-oxoacyl-[acyl-carrier protein] + NADPH | Brassica napus | enzyme is part of the dissociable fatty acid synthase type II multienzyme complex for de novo synthesis of fatty acids from acetyl-CoA and malonyl-CoA | (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
? | |
3-oxoacyl-[acyl-carrier protein] + NADPH | Brassica napus | enzyme in fatty acid synthesis | (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
? | |
additional information | Escherichia coli | catalyzes also the reduction of the beta-keto group of unsaturated acyl chains during biosynthesis of unsaturated fatty acids | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brassica napus | - |
- |
- |
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+ | belongs to family of short-chain alcohol dehydrogenases (SDR) with catalytic triad Ser154, Tyr167 and Lys171, catalytic mechanism | Brassica napus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-oxoacyl-[acyl-carrier protein] + NADPH | - |
Escherichia coli | (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
? | |
3-oxoacyl-[acyl-carrier protein] + NADPH | belongs to family of short-chain alcohol dehydrogenases (SDR) with catalytic triade Ser154, Tyr167 and Lys171, catalytic mechanism | Brassica napus | (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
? | |
3-oxoacyl-[acyl-carrier protein] + NADPH | enzyme is part of the dissociable fatty acid synthase type II multienzyme complex for de novo synthesis of fatty acids from acetyl-CoA and malonyl-CoA | Brassica napus | (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
? | |
3-oxoacyl-[acyl-carrier protein] + NADPH | enzyme in fatty acid synthesis | Brassica napus | (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ | - |
? | |
acetoacetyl-CoA + NADPH + H+ | - |
Escherichia coli | D-beta-hydroxybutyryl-CoA + NADP+ | - |
? | |
acetoacetyl-CoA + NADPH + H+ | - |
Brassica napus | D-beta-hydroxybutyryl-CoA + NADP+ | - |
? | |
acetoacetyl-N-cysteamine + NADPH | - |
Escherichia coli | D-3-hydroxybutyryl-N-cysteamine + NADP+ | - |
? | |
acetoacetyl-N-cysteamine + NADPH | - |
Brassica napus | D-3-hydroxybutyryl-N-cysteamine + NADP+ | - |
? | |
acetoacetyl-[acyl-carrier protein] + NADPH | - |
Escherichia coli | D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+ | - |
? | |
acetoacetyl-[acyl-carrier protein] + NADPH | - |
Brassica napus | D-beta-hydroxybutyryl-[acyl-carrier protein] + NADP+ | - |
? | |
additional information | catalyzes also the reduction of the beta-keto group of unsaturated acyl chains during biosynthesis of unsaturated fatty acids | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BKR | - |
Escherichia coli |
BKR | - |
Brassica napus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | absolute specificity for NADPH | Escherichia coli | |
NADPH | absolute specificity for NADPH | Brassica napus |