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Literature summary for 1.1.1.1 extracted from

  • Kollock, R.; Frank, H.; Seidel, A.; Meinl, W.; Glatt, H.
    Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases (2008), Toxicology, 245, 65-75.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-Methylpyrazole
-
Homo sapiens
DMSO DMSO inhibits isozyme ADH2-catalysed oxidation in an uncompetitive mode and reduction in a mixed mode; DMSO inhibits isozymes ADH1C-catalysed oxidation in an uncompetitive mode and reduction in a mixed mode, no inhibition is detected with isozyme ADH3; DMSO inhibits isozymes ADH4-catalysed oxidation in an uncompetitive mode and reduction in a mixed mode Homo sapiens
ethanol ethanol competitively inhibits the oxidation of 1-hydroxymethylpyrene by ADH1C and ADH3; ethanol competitively inhibits the oxidation of 1-hydroxymethylpyrene by ADH4 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000035
-
1-formyl-8-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.000036
-
1-formyl-6-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.00024
-
1-formyl-8-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.00028
-
1-hydroxymethyl-6-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.00031
-
1-hydroxymethyl-8-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.00032
-
1-formyl-6-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.00037
-
4-hydroxymethylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.00048
-
2-hydroxymethylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.00048
-
4-formylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.0005
-
1-formylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.00055
-
1-formylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.00057
-
1-hydroxymethyl-6-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.00059
-
1-hydroxymethylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.00075
-
1-hydroxymethylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.0009
-
1-formyl-6-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.00092
-
1-formylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.001
-
4-formylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.001
-
4-hydroxymethylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.00115
-
1-hydroxymethyl-6-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.00131
-
1-formyl-8-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.00149
-
1-formyl-8-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.0016
-
1-hydroxymethyl-8-methylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.0021
-
2-formylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.0021
-
4-formylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.0029
-
2-formylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.0029
-
4-hydroxymethylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.0038
-
4-formylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.0038
-
1-formyl-6-methylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.0044
-
2-hydroxymethylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.0064
-
1-hydroxymethyl-6-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.0064
-
1-hydroxymethyl-8-methylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.0069
-
2-formylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.009
-
2-formylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.012
-
1-formylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.0283
-
1-hydroxymethylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.033
-
2-hydroxymethylpyrene isozyme ADH4, at 21-23°C Homo sapiens
0.04
-
4-hydroxymethylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.059
-
1-hydroxymethyl-8-methylpyrene isozyme ADH1C, at 21-23°C Homo sapiens
0.076
-
1-hydroxymethylpyrene isozyme ADH2, at 21-23°C Homo sapiens
0.106
-
2-hydroxymethylpyrene isozyme ADH3, at 21-23°C Homo sapiens
0.34
-
acetaldehyde isozyme ADH1C, at 21-23°C Homo sapiens
0.39
-
1-Octanol isozyme ADH3, at 21-23°C Homo sapiens
0.77
-
ethanol isozyme ADH1C, at 21-23°C Homo sapiens
3.6
-
ethanol isozyme ADH4, at 21-23°C Homo sapiens
9.6
-
octanal isozyme ADH3, at 21-23°C Homo sapiens
12.7
-
acetaldehyde isozyme ADH4, at 21-23°C Homo sapiens
26
-
acetaldehyde isozyme ADH2, at 21-23°C Homo sapiens
33
-
ethanol isozyme ADH2, at 21-23°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39500
-
isozyme ADH3, apparent molecular weight deduced from electrophoretic mobility Homo sapiens
39720
-
isozyme ADH3, calculated from amino acid sequence Homo sapiens
39870
-
isozyme ADH1C, calculated from amino acid sequence Homo sapiens
40000
-
isozyme ADH2, apparent molecular weight deduced from electrophoretic mobility Homo sapiens
40000
-
isozyme ADH4, calculated from amino acid sequence Homo sapiens
40220
-
isozyme ADH2, calculated from amino acid sequence Homo sapiens
40500
-
isozyme ADH1C, apparent molecular weight deduced from electrophoretic mobility Homo sapiens
40500
-
isozyme ADH4, apparent molecular weight deduced from electrophoretic mobility Homo sapiens

Organic Solvent Stability

Organic Solvent Comment Organism
DMSO DMSO is not an ideal substrate-delivering solvent for ADH-catalysed reactions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00326
-
-
Homo sapiens P08319
-
-

Source Tissue

Source Tissue Comment Organism Textmining
buccal mucosa isozyme ADH4 Homo sapiens
-
liver isozymes ADH1C and ADH3 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-hydroxymethyl-6-methylpyrene + NAD+
-
Homo sapiens 1-formyl-6-methylpyrene + NADH + H+
-
r
1-hydroxymethyl-8-methylpyrene + NAD+
-
Homo sapiens 1-formyl-8-methylpyrene + NADH + H+
-
r
1-hydroxymethylpyrene + NAD+
-
Homo sapiens 1-formylpyrene + NADH + H+
-
r
1-octanol + NAD+ substrate for isozyme ADH3 Homo sapiens octanal + NADH + H+
-
r
2-hydroxymethylpyrene + NAD+
-
Homo sapiens 2-formylpyrene + NADH + H+
-
r
4-hydroxymethylpyrene + NAD+
-
Homo sapiens 4-formylpyrene + NADH + H+
-
r
ethanol + NAD+ substrate for isozyme ADH1C, extremely poor substrate for isozyme ADH3 Homo sapiens acetaldehyde + NADH + H+
-
r
ethanol + NAD+ substrate for isozyme ADH2 Homo sapiens acetaldehyde + NADH + H+
-
r
ethanol + NAD+ substrate for isozyme ADH4 Homo sapiens acetaldehyde + NADH + H+
-
r
additional information 1-octanal is no substrate for isozyme ADH1C Homo sapiens ?
-
?
additional information 1-octanal is no substrate for isozyme ADH2 Homo sapiens ?
-
?
additional information 1-octanal is no substrate for isozyme ADH4 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ADH1C isozyme Homo sapiens
ADH2 isozyme Homo sapiens
ADH3 isozyme Homo sapiens
ADH4 isozyme Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.7
-
ethanol isozyme ADH1C, using 1-hydroxymethylpyrene as substrate Homo sapiens
3.3
-
ethanol isozyme ADH4, using 1-hydroxymethylpyrene as substrate Homo sapiens
1470
-
ethanol isozyme ADH3, using 1-hydroxymethylpyrene as substrate Homo sapiens