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Literature summary for 1.1.1.1 extracted from

  • Haseba, T.; Sugimoto, J.; Sato, S.; Abe, Y.; Ohno, Y.
    Phytophenols in whisky lower blood acetaldehyde level by depressing alcohol metabolism through inhibition of alcohol dehydrogenase 1 (class I) in mice (2008), Metab. Clin. Exp., 57, 1753-1759.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
caffeic acid mixed type of inhibition Mus musculus
ellagic acid mixed type of inhibition Mus musculus
pyrazole
-
Mus musculus
syringaldehyde mixed type of inhibition Mus musculus
Vanillin mixed type of inhibition Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethanol + NAD+
-
Mus musculus acetaldehyde + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
ADH 1
-
Mus musculus
alcohol dehydrogenase 1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00008
-
caffeic acid at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
0.0051
-
pyrazole at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
0.0079
-
Vanillin at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
0.0156
-
syringaldehyde at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
0.022
-
ellagic acid at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus